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Assessment of a rapid liquid-based cytology method for measuring sputum cell counts
  1. M J Martin1,
  2. H Lee1,
  3. G Meakin1,
  4. A Green1,
  5. R L Simms1,
  6. C Reynolds1,
  7. S Winters2,
  8. D E Shaw1,
  9. I Soomro2,
  10. T W Harrison1
  1. 1The Asthma Centre, Nottingham Respiratory Research Unit, University of Nottingham, Nottingham City Hospital, Nottingham, UK
  2. 2Department of Cellular Pathology, Nottingham University Hospitals NHS Trust, Nottingham City Hospital, Nottingham, UK
  1. Correspondence to Professor Tim Harrison, Room B23, Clinical Sciences Building, Nottingham City Hospital, Hucknall Rd, Nottingham NG5 1PB, UK;tim.harrison{at}


Differential sputum cell counting is not widely available despite proven clinical utility in the management of asthma. We compared eosinophil counts obtained using liquid-based cytology (LBC), a routine histopathological processing method, and the current standard method. Eosinophil counts obtained using LBC were a strong predictor of sputum eosinophilia (≥3%) determined by the standard method suggesting LBC could be used in the management of asthma.

  • Asthma
  • Histology/Cytology

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