Article Text

other Versions

PDF
Original article
Air pollution affects lung cancer survival
  1. Sandrah P Eckel1,
  2. Myles Cockburn1,
  3. Yu-Hsiang Shu1,2,
  4. Huiyu Deng1,
  5. Frederick W Lurmann3,
  6. Lihua Liu1,
  7. Frank D Gilliland1
  1. 1Department of Preventive Medicine, University of Southern California, Los Angeles, California, USA
  2. 2Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, California, USA
  3. 3Sonoma Technology Inc., Petaluma, California, USA
  1. Correspondence to Dr Sandrah P Eckel, Department of Preventive Medicine, University of Southern California, 2001 N. Soto Street, MC-9234, Los Angeles, CA 90089, USA; eckel{at}usc.edu

Abstract

Rationale Exposure to ambient air pollutants has been associated with increased lung cancer incidence and mortality, but due to the high case fatality rate, little is known about the impacts of air pollution exposures on survival after diagnosis. This study aimed to determine whether ambient air pollutant exposures are associated with the survival of patients with lung cancer.

Methods Participants were 352 053 patients with newly diagnosed lung cancer during 1988–2009 in California, ascertained by the California Cancer Registry. Average residential ambient air pollutant concentrations were estimated for each participant's follow-up period. Cox proportional hazards models were used to estimate HRs relating air pollutant exposures to all-cause mortality overall and stratified by stage (localised only, regional and distant site) and histology (squamous cell carcinoma, adenocarcinoma, small cell carcinoma, large cell carcinoma and others) at diagnosis, adjusting for potential individual and area-level confounders.

Results Adjusting for histology and other potential confounders, the HRs associated with 1 SD increases in NO2, O3, PM10, PM2.5 for patients with localised stage at diagnosis were 1.30 (95% CI 1.28 to 1.32), 1.04 (95% CI 1.02 to 1.05), 1.26 (95% CI 1.25 to 1.28) and 1.38 (95% CI 1.35 to 1.41), respectively. Adjusted HRs were smaller in later stages and varied by histological type within stage (p<0.01, except O3). The largest associations were for patients with early-stage non-small cell cancers, particularly adenocarcinomas.

Conclusions These epidemiological findings support the hypothesis that air pollution exposures after lung cancer diagnosis shorten survival. Future studies should evaluate the impacts of exposure reduction.

  • Lung Cancer
  • Clinical Epidemiology

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Linked Articles