Article Text

other Versions

PDF
Original article
Lung function in woodsmoke-exposed Guatemalan children following a chimney stove intervention
  1. Amy P Heinzerling1,
  2. Michael J Guarnieri1,
  3. Jennifer K Mann2,
  4. Janet V Diaz1,
  5. Lisa M Thompson3,
  6. Anaite Diaz4,
  7. Nigel G Bruce5,
  8. Kirk R Smith2,
  9. John R Balmes1,2
  1. 1Department of Medicine, University of California San Francisco, California, USA
  2. 2Department of Environmental Health Sciences, School of Public Health, University of California, Berkeley, California, USA
  3. 3School of Nursing, University of California, San Francisco, California, USA
  4. 4Center for Health Studies, Universidad del Valle de Guatemala, Guatemala
  5. 5Department of Public Health and Policy, University of Liverpool, Liverpool, UK
  1. Correspondence to Dr John R Balmes, University of California San Francisco, Box 0843, San Francisco CA 94143-0843, USA; John.Balmes{at}ucsf.edu

Abstract

Rationale Household air pollution (HAP) from solid fuel combustion is a major contributor to the global burden of disease, with considerable impact from respiratory infections in children. The impact of HAP on lung function is unknown.

Objectives The Childhood Exposure to Respirable Particulate Matter (CRECER) prospective cohort study followed Guatemalan children who participated in the Randomised Exposure Study of Pollution Indoors and Respiratory Effects (RESPIRE) trial of a chimney stove intervention to determine the effect of early childhood HAP exposure on growth of lung function.

Methods RESPIRE households with pregnant women or infant children were randomised to receive a chimney stove at the beginning or at the end of the 18-month trial. During CRECER, a subset of these children, as well as children from households with newly installed stoves, were followed with spirometry beginning at age 5. Biomass smoke exposure was measured using personal carbon monoxide tubes. Two-stage regression models were employed to analyse associations with lung function growth.

Measurements and main results Longitudinal peak expiratory flow (PEF) and FEV1 data were available for 443 and 437 children, respectively, aged 5–8 (mean follow-up 1.3 years). Decreases in PEF growth of 173 mL/min/year (95% CI −341 to −7) and FEV1 of 44 mL/year (95% CI −91 to 4) were observed with stove installation at 18 months compared with stove installation at birth in analyses adjusted for multiple covariates. No statistically significant associations were observed between personal HAP exposure and lung function.

Conclusions A significant decrease in PEF growth and a large non-significant decrease in FEV1 growth were observed with later stove installation. Additional studies including longer follow-up and cleaner stoves or fuels are needed.

  • Lung Physiology
  • Paediatric Lung Disaese

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Linked Articles