Article Text

other Versions

PDF
Lung transplantation for pulmonary sarcoidosis. Twenty-five years of experience in the USA
  1. Ziad Taimeh1,
  2. Marshall I Hertz2,
  3. Sara Shumway3,
  4. Marc Pritzker1
  1. 1Lillehei Heart Institute, University of Minnesota School of Medicine, Minneapolis, Minnesota, USA
  2. 2Department of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Minnesota School of Medicine, Minneapolis, Minnesota, USA
  3. 3Department of Cardiothoracic Surgery, University of Minnesota School of Medicine, Minneapolis, Minnesota, USA
  1. Correspondence to Dr Ziad Taimeh, Lillehei Heart Institute, University of Minnesota School of Medicine, 420 Delaware street SE, MMC 508, Minneapolis, MN 55455, USA; taime001{at}umn.edu

Abstract

Objective Lung transplantation is the ultimate treatment for end-stage pulmonary sarcoidosis. Post-transplant survival outcomes remain unclear.

Methods Survival models were used to assess survival and graft outcomes in patients with sarcoid among 20 896 lung transplants performed in the USA.

Results 695 lung recipients were transplanted for pulmonary sarcoidosis. Sarcoid lung recipients had similar median survival rate (69.7 months (IQR 60.2–79.3)) compared with the non-sarcoid lung recipients (63.1 months (IQR 61.4–64.8), p=0.88). In multivariate Cox regression, sarcoidosis was not independently associated with worse mortality (HR 0.96 (95% CI 0.85 to 1.08), p=0.51). Among the sarcoid lung recipients, double lung transplantation (HR 0.76 (0.58 to 0.99), p=0.04) and lung allocation score era (HR 0.74 (0.56 to 0.97), p=0.03) were associated with improved survival.

Conclusions Recipients of lung transplants for pulmonary sarcoidosis had similar outcomes compared with non-sarcoid lung recipients.

  • Lung Transplantation
  • Sarcoidosis

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.