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Audit, research and guideline update
‘LungGENS’: a web-based tool for mapping single-cell gene expression in the developing lung
  1. Yina Du1,
  2. Minzhe Guo1,2,
  3. Jeffrey A Whitsett1,
  4. Yan Xu1,3
  1. 1Department of Perinatal and Pulmonary Biology, The Perinatal Institute and Section of Neonatology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA
  2. 2Department of Electrical Engineering and Computing Systems, University of Cincinnati, Cincinnati, Ohio, USA
  3. 3Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA
  1. Correspondence to Dr Yan Xu, Divisions of Pulmonary Biology, Perinatal Institute and Biomedical Informatics, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC7029, Cincinnati, OH 45229-3039, USA; Yan.Xu{at}cchmc.org

Abstract

We developed LungGENS (Lung Gene Expression iN Single-cell), a web-based bioinformatics resource for querying single-cell gene expression databases by entering a gene symbol or a list of genes or selecting a cell type of their interest. Gene query provides quantitative RNA expression of the gene of interest in each lung cell type. Cell type query returns associated selective gene signatures and genes encoding cell surface markers and transcription factors in interactive heatmap and tables. LungGENS will be broadly applicable in respiratory research, providing a cell-specific RNA expression resource at single-cell resolution. LungGENS is freely available for non-commercial use at https://research.cchmc.org/pbge/lunggens/default.html.

  • Systemic disease and lungs
  • Surfactant protein
  • TTF-1
  • Airway Epithelium

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