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Research letter
Clinical application of autologous technetium-99m-labelled eosinophils to detect focal eosinophilic inflammation in the lung
  1. Chrystalla Loutsios1,
  2. Neda Farahi1,
  3. Rosalind Simmonds1,
  4. Ian Cullum2,
  5. Daniel Gillett2,
  6. Chandra Solanki2,
  7. Kishor Solanki2,
  8. John Buscombe2,
  9. Alison M Condliffe1,
  10. A Mike Peters3,
  11. Edwin R Chilvers1
  1. 1Division of Respiratory Medicine, Department of Medicine, University of Cambridge, Cambridge, UK
  2. 2Department of Nuclear Medicine, Addenbrooke's Hospital, Cambridge, UK
  3. 3Clinical Imaging Sciences Centre, Brighton and Sussex Medical School, Brighton, UK
  1. Correspondence to Professor Edwin R Chilvers, Division of Respiratory Medicine, Department of Medicine, University of Cambridge, Box 157, Level 5, Addenbrooke's and Papworth Hospitals, Cambridge CB2 0QQ, UK; erc24{at}cam.ac.uk

Abstract

Abstract The detection of focal eosinophilic inflammation by non-invasive means may aid the diagnosis and follow-up of a variety of pulmonary pathologies. All current methods of detection involve invasive sampling, which may be contraindicated or too high-risk to be performed safely. The use of injected autologous technetium-99m (Tc-99m)-labelled eosinophils coupled to single-photon emission computed tomography (SPECT) has been demonstrated to localise eosinophilic inflammation in the lungs of a patient with antineutrophil cytoplasmic antibody-positive vasculitis. Here, we report on the utility of this technique to detect active eosinophilic inflammation in a patient with focal lung inflammation where a biopsy was contraindicated.

  • Eosinophil Biology
  • Imaging/CT MRI etc
  • Pulmonary eosinophilia

This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/

https://doi.org/10.1136/thoraxjnl-2015-207156

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