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Audit, Research and Guideline update
The Canadian Healthy Infant Longitudinal Development (CHILD) Study: examining developmental origins of allergy and asthma
  1. Padmaja Subbarao1,
  2. Sonia S Anand2,
  3. Allan B Becker3,
  4. A Dean Befus4,
  5. Michael Brauer5,
  6. Jeffrey R Brook6,
  7. Judah A Denburg2,
  8. Kent T HayGlass3,
  9. Michael S Kobor5,
  10. Tobias R Kollmann5,
  11. Anita L Kozyrskyj4,
  12. W Y Wendy Lou7,
  13. Piushkumar J Mandhane4,
  14. Gregory E Miller8,
  15. Theo J Moraes1,
  16. Peter D Pare5,
  17. James A Scott7,
  18. Tim K Takaro9,
  19. Stuart E Turvey5,
  20. Joanne M Duncan2,
  21. Diana L Lefebvre2,
  22. Malcolm R Sears2
  23. the CHILD Study investigators
    1. 1Department of Pediatrics, Hospital for Sick Children and University of Toronto, Toronto, Canada
    2. 2McMaster University, Hamilton, Canada
    3. 3University of Manitoba, Winnipeg, Canada
    4. 4University of Alberta, Edmonton, Canada
    5. 5University of British Columbia, Vancouver, Canada
    6. 6Environment Canada, Toronto, Canada
    7. 7University of Toronto, Toronto, Canada
    8. 8Northwestern University, Chicago, USA
    9. 9Simon Fraser University, Vancouver, Canada
    1. Correspondence to Dr Padmaja Subbarao, Department of Pediatrics, Hospital for Sick Children, 555 University Avenue, Toronto ON, M5G 1X8, USA; padmaja.subbarao{at}sickkids.ca

    Abstract

    The Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort study recruited 3624 pregnant women, most partners and 3542 eligible offspring. We hypothesise that early life physical and psychosocial environments, immunological, physiological, nutritional, hormonal and metabolic influences interact with genetics influencing allergic diseases, including asthma. Environmental and biological sampling, innate and adaptive immune responses, gene expression, DNA methylation, gut microbiome and nutrition studies complement repeated environmental and clinical assessments to age 5. This rich data set, linking prenatal and postnatal environments, diverse biological samples and rigorous phenotyping, will inform early developmental pathways to allergy, asthma and other chronic inflammatory diseases.

    • Asthma
    • Asthma Epidemiology
    • Asthma Genetics
    • Asthma Mechanisms
    • Paediatric asthma
    • Viral infection
    • Allergic lung disease
    • Respiratory Measurement

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