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Pulmonary puzzles
Pleural nodules in a patient with a colonic tumour
  1. Edson Marchiori1,
  2. Rosana Souza Rodrigues1,2,
  3. Mario Celso Martins Reis1,
  4. Gláucia Zanetti1,
  5. Miriam Menna Barreto1
  1. 1Department of Radiology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
  2. 2D'Or Institute for Research and Education, Rio de Janeiro, Brazil
  1. Correspondence to Professor Edson Marchiori, Department of Radiology, Federal University of Rio de Janeiro, Rua Thomaz Cameron, 438, Valparaiso, Petrópolis, Rio de Janeiro CEP 25685.120, Brazil; edmarchiori{at}gmail.com

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Case presentation

A 58-year-old woman underwent chest CT to monitor a colonic tumour diagnosed 1 year previously. Axial and coronal CT images showed multiple well-circumscribed pleural-based nodules in the left lower hemithorax, and the absence of the spleen in the left upper quadrant (figure 1). Routine blood work demonstrated no significant laboratory abnormality. The patient also had a history of a gunshot wound that transfixed the thoracoabdominal region 40 years previously. Thoracotomy was performed and disclosed multiple reddish-purple nodules on the pleural surface (figure 2).

Figure 1

Axial (A) and coronal (B) CT images showed multiple pleural nodules in the left hemithorax and the absence of the spleen in the left upper quadrant of the abdomen.

Figure 2

Thoracotomy disclosed multiple reddish-purple nodules on the pleural surface.

What is the most probable diagnosis of the pleural nodules?

Answer

Clinical and CT findings suggested a differential diagnosis between pleural metastasis and splenosis. Histopathology revealed normal splenic tissue, allowing the diagnosis of pleural splenosis.

Thoracic splenosis (TS) is a benign acquired condition involving the autotransplantation of splenic tissue into the pleural cavity. It frequently results from left upper abdominal trauma with concomitant splenic damage and left diaphragmatic tear. Splenic tissue gains access to the left pleural space and derives its blood supply from the pleura, chest wall or diaphragm. TS is usually asymptomatic and found incidentally by imaging examinations performed for other reasons. It rarely causes chest pain or haemoptysis.1–5 The average interval between trauma and TS diagnosis is ∼20 years.

Splenic implants are sessile or pedunculated reddish-blue nodules of normal splenic tissue with diameters ranging from a few millimetres to several centimetres.2 They may occur on the parietal or visceral pleura. Splenic function may be partially or totally recovered, depending on the amount of ectopic splenic tissue.4 There is no reason to remove asymptomatic splenic tissue implants because they probably offer some degree of protection against bacterial infection.2 ,3

In most cases, chest CT shows multiple or solitary pleural-based nodules ≤3 cm in diameter (some may be larger and form masses)4 with an attenuation similar to that of the normal spleen.3 ,5 The preoperative diagnostic modality of choice is nuclear scintigraphy with technetium 99m sulfur colloid, indium 111–labelled platelets or 99mTc heat-damaged erythrocytes.1–3 ,5

Due to the resemblance of TS to malignancy in diagnostic imaging studies, the majority of patients have undergone extensive workups or invasive procedures.2 Differential considerations include pleural metastases, lymphoma, localised fibrous tumour of the pleura, malignant mesothelioma and invasive thymoma.3 A history of thoracoabdominal trauma and/or splenectomy and the finding of left-sided pleural-based nodules should indicate a diagnosis of TS.

References

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Footnotes

  • Contributors MMB, RSR, MCMR and GZ designed the study. MMB, RSR, MCMR, GZ and EM analysed the samples and the data. MMB and EM wrote the manuscript, and all authors revised and checked it.

  • Competing interests None.

  • Patient consent Obtained.

  • Ethics approval The ethics committee/institutional review board waived the approvation.

  • Provenance and peer review Not commissioned; internally peer reviewed.

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