• Cystic Fibrosis

Short palate lung and nasal epithelial clone 1 (SPLUNC1) is the most abundant secreted protein in the airways and helps maintain a normal airway surface liquid (ASL) volume through its regulation of the epithelial Na⁺ channel (ENaC). In cystic fibrosis (CF), it has been proposed that increased Na⁺ absorption by ENaC contributes to ASL depletion, despite the presence of SPLUNC1.

The study by Garland et …