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Miscellanea
Journal club
A novel mechanism for MET and EGFR axis regulation in non-small cell lung cancer involving microRNA-27a and Sprouty2
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  1. Omair Shariq
  1. Correspondence to Dr Omair Shariq, Department of Surgery, Chelsea and Westminster Hospital NHS Trust, 369 Fulham Road, London SW10 9NH, UK; omair.shariq{at}gmail.com

https://doi.org/10.1136/thoraxjnl-2013-204084

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    Epidermal growth factor receptor (EGFR) and hepatocyte growth factor receptor (MET) are tyrosine kinase receptors that have been implicated in the pathogenesis of non-small cell lung cancer (NSLC). Sprouty2, a ubiquitously expressed protein, has been shown to upregulate EGFR and MET in several types of cancers. Conversely, microRNAs are small non-coding RNA molecules that regulate gene expression negatively, …

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