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  • Short-term use of clarithromycin in lower respiratory tract infections may increase long-term risk of cardiovascular mortality and morbidity

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Short-term use of clarithromycin in lower respiratory tract infections may increase long-term risk of cardiovascular mortality and morbidity
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  1. Haider Al-Najjar
  1. Correspondence to Dr Haider Al-Najjar, SPR in Respiratory, Southmead Hospital, Southmead Road, Bristol BS10 5NB, UK; haidernajjar{at}hotmail.com

https://doi.org/10.1136/thoraxjnl-2013-204080

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    Macrolides are commonly prescribed for chronic obstructive pulmonary disease (COPD) exacerbations and community-acquired pneumonia. The short-term cardiovascular effects, probably due to QT prolongation, are well documented and some studies have implicated macrolides with increased mortality in patients with pre-existing coronary disease.

    This study evaluated the association between clarithromycin use and cardiovascular events in patients treated for lower respiratory tract infections in a secondary analysis of two prospective …

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