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Chest clinic
Opinion
Against all odds: anti-IgE for intrinsic asthma?
  1. Marek Lommatzsch1,
  2. Stephanie Korn2,
  3. Roland Buhl2,
  4. Johann Christian Virchow1
  1. 1Department of Pneumology and Critical Care Medicine, University of Rostock, Rostock, Germany
  2. 2Pulmonary Department, Mainz University Hospital, Mainz, Germany
  1. Correspondence to Dr Marek Lommatzsch, Abteilung für Pneumologie und Internistische Intensivmedizin, Zentrum für Innere Medizin, Universität Rostock, Ernst-Heydemann-Str. 6, Rostock 18057, Germany; marek.lommatzsch{at}med.uni-rostock.de

Abstract

For many years, pathogenetic concepts and the results of clinical trials supported the view that anti-IgE treatment is specifically effective in allergic asthma. However, there is now growing clinical and mechanistic evidence suggesting that treatment with the anti-IgE antibody omalizumab can be effective in patients with intrinsic asthma. Therefore, large and well-controlled clinical trials with anti-IgE are urgently warranted in patients with intrinsic asthma. In addition, there is a need to find new biomarkers which can identify patients with asthma who respond to anti-IgE treatment.

  • Asthma
  • Asthma Mechanisms
  • Asthma Pharmacology

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 3.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/3.0/

https://doi.org/10.1136/thoraxjnl-2013-203738

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