Against all odds: anti-IgE for intrinsic asthma?
- 1Department of Pneumology and Critical Care Medicine, University of Rostock, Rostock, Germany
- 2Pulmonary Department, Mainz University Hospital, Mainz, Germany
- Correspondence to Dr Marek Lommatzsch, Abteilung für Pneumologie und Internistische Intensivmedizin, Zentrum für Innere Medizin, Universität Rostock, Ernst-Heydemann-Str. 6, Rostock 18057, Germany;
- Received 14 April 2013
- Revised 19 April 2013
- Accepted 26 April 2013
- Published Online First 24 May 2013
For many years, pathogenetic concepts and the results of clinical trials supported the view that anti-IgE treatment is specifically effective in allergic asthma. However, there is now growing clinical and mechanistic evidence suggesting that treatment with the anti-IgE antibody omalizumab can be effective in patients with intrinsic asthma. Therefore, large and well-controlled clinical trials with anti-IgE are urgently warranted in patients with intrinsic asthma. In addition, there is a need to find new biomarkers which can identify patients with asthma who respond to anti-IgE treatment.
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