Nicotine replacement therapy in pregnancy
- Correspondence to Dr John D Blakey, Clinical Lecturer, Respiratory Medicine, Clinical Sciences Building, City Hospital Campus, Nottingham NG5 1PB, UK;
Cigarette smoking is a major modifiable cause of adverse pregnancy outcomes. Nicotine-replacement therapy (NRT) is recommended in guidelines, but its efficacy and safety during pregnancy is uncertain.
This multicentre double-blind trial recruited 1050 pregnant participants who were in their 12–24 weeks' gestation periods. All of them smoked ≥5 cigarettes per day (median 20). Participants were randomly assigned …