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Restoration of function of the ∆F508 mutation in cystic fibrosis
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  1. Stephen Rowan
  1. Correspondence to Dr Stephen Rowan, Belfast City Hospital, Belfast, UK; stephen_rowan{at}hotmail.com

https://doi.org/10.1136/thoraxjnl-2012-201828

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    The first nucleotide binding domain (NBD1) of the of ∆F508 cystic fibrosis transmembrane conductance regulator (CFTR), is considered a potential drug target in cystic fibrosis but the links between this and CFTR misfolding remain unclear. NBD1 is one of the cytosolic domains of CFTR and is found in at …

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