Sleep apnoea attenuates the effects of a lifestyle intervention programme in men with visceral obesity
- Anne-Laure Borel1,
- Xavier Leblanc2,
- Natalie Alméras1,
- Angelo Tremblay1,3,
- Jean Bergeron4,
- Paul Poirier1,
- Jean-Pierre Després1,3,
- Frédéric Series1
- 1Centre de recherche, Institut universitaire de cardiologie et de pneumologie de Québec, Québec, Canada
- 2Faculty of Medicine, Université Laval, Québec, Canada
- 3Department of Social and Preventive Medicine, Division of Kinesiology, Université Laval, Québec, Canada
- 4Lipid Research Center, CHUQ Research Center, Québec, Canada
- Correspondence to Dr Frédéric Sériès, Department of Pneumology, Institut universitaire de cardiologie et de pneumologie de Québec, 2725 Chemin Sainte-Foy, G1V 4G5 Québec, Canada;
Contributors All authors have substantially contributed to the study by participating in conception and design, or analysis and interpretation of data, drafting the paper or revising it critically for important intellectual content and have given their final approval of the version to be published. ALB: analysed data and wrote the paper. XL: contributed to data analysis; NA, AT, JB, PP, JPD, FS: researched data, contributed to discussion and reviewed/edited the paper.
- Received 26 August 2011
- Accepted 14 February 2012
- Published Online First 6 March 2012
Background Excess visceral adiposity and sleep apnoea are two conditions independently associated with cardiovascular diseases. The two conditions are often combined and are believed to interact in a vicious circle.
Objectives To compare the response of men with visceral obesity with or without sleep apnoea syndrome to a 1-year healthy eating, physical activity/exercise intervention programme.
Methods 77 men, selected on the basis of increased waist circumference (≥90 cm) and dyslipidaemia (triglycerides ≥1.69 and/or high-density lipoprotein (HDL) cholesterol <1.03 mmol/litre), participated in this study. Body composition and fat distribution were assessed by dual-emission X-ray absorptiometry or CT and sleep breathing disorders by home-based polygraphic recording. Cardiorespiratory fitness, plasma adipokines, plasma inflammatory markers, fasting lipoprotein–lipid profile and oral glucose tolerance test were assessed.
Results After the 1-year lifestyle intervention, the mean oxygen desaturation index (ODI) of the whole sample decreased (−3±13 events/h, p<0.05). Men with sleep apnoea syndrome at baseline (ODI ≥10 events/h, n=28) showed smaller reductions in body mass index, waist circumference, triglycerides and smaller increases in HDL cholesterol and adiponectin than men without sleep apnoea (ODI <10 events/h, n=49), despite similar compliance to the programme. The higher the baseline ODI and the time spent under 90% saturation, the lower the reductions in fat mass and visceral adiposity, and the smaller the improvement in glucose/insulin homeostasis indices after 1 year.
Conclusions Men with sleep apnoea syndrome at baseline had smaller reduction in body weight and less metabolic improvements associated with the lifestyle intervention programme than men without sleep apnoea syndrome.
- Intra-abdominal fat
- sleep apnoea syndrome
- cardiometabolic risk
- clinical epidemiology
- sleep apnoea
- respiratory measurement
- respiratory muscles
Funding This study was supported by the Canadian Institutes of Health Research: CIHR grant 89985 and the National Institute for Public Research.
Competing interests None.
Patient consent Obtained.
Ethics approval Ethics approval was provided by the Medical Ethics Committees of Université Laval and Institut universitaire de cardiologie et de pneumologie de Québec.
Provenance and peer review Not commissioned; externally peer reviewed.