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Thorax doi:10.1136/thoraxjnl-2011-200657
  • PostScript
  • Correspondence

Pragmatic trials: how to adjust for the ‘Hawthorne effect’?

  1. George N Konstantinou1,2
  1. 1Department of Allergy and Clinical Immunology, 424 General Military Training Hospital, Thessaloniki, Greece
  2. 2Jaffe Food Allergy Institute, Immunology Institute, Mount Sinai School of Medicine, New York, USA
  1. Correspondence to Dr George N Konstantinou, Department of Allergy and Clinical Immunology, 424 General Military Training Hospital, 21 Sirou Str, Thessaloniki, Greece; gnkonstantinou{at}gmail.com
  • Accepted 14 July 2011
  • Published Online First 23 August 2011

Hashimoto et al1 have conducted an interesting study to offer a practical and pragmatic insight into steroid-dependent asthma therapeutics in real-world practice. They proposed a strategy based on internet monitoring of objective (spirometry and fraction of exhaled nitric oxide) and subjective (asthma control and asthma-related quality of life questionnaires) measurements to adjust the dose of oral corticosteroids in patients with severe, uncontrolled asthma. However, how ‘pragmatic’ is …

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Relevant Article

  • PostScript: Correspondence: Authors' response
    • Simone Hashimoto,
    • Peter J Sterk,
    • Elisabeth H Bel
    Thorax 2012;67:6 562 Published Online First: 23 August 2011 doi:10.1136/thoraxjnl-2011-200870

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