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Correspondence
Exit of leucocytes across the alveolar epithelium worsens lung injury
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  1. Joanna C Porter
  1. Correspondence to Dr Joanna C Porter, University College London, London, UK; joanna.porter{at}ucl.ac.uk

https://doi.org/10.1136/thx.2010.157065

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    Persson and Uller are to be commended for their review highlighting the important role of leucocyte egression in the resolution of airway inflammation.1 They go on to speculate that egression across the alveolar epithelium may be detrimental, because, unlike for the airways, there is no mucociliary escalator, and luminal cells that are not removed will interfere with gas exchange. They allay this concern citing work from Cory et al2 using a mousemodel of asthma. In this model a deficiency of matrix metalloproteinase (MMP)-2 …

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      Carl G Persson Lena Uller
      Thorax 2011; 66 1095-1096 Published Online First: 20 Apr 2011. doi: 10.1136/thx.2010.158220