Author's response: can cells other than Th17 lymphocytes be important sources of IL-17 in the lung?
- Monica Facco1,2,
- Anna Cabrelle1,2,
- Carlo Agostini1,2
- 1Department of Clinical and Experimental Medicine, Hematology-Immunology Section, Padua University School of Medicine, Padova, Italy
- 2Venetian Institute of Molecular Medicine, Padua University School of Medicine, Padova, Italy
- Correspondence to Prof Agostini Carlo, Padua University School of Medicine, Giustiniani 2, Padova, 35128, Italy; carlo.agostini{at}unipd.it
- Accepted 17 January 2011
- Published Online First 15 March 2011
We thank Dr Brodlie and coworkers for their letter1 and fully agree on the necessity to evaluate whether cells other than lymphocytes and macrophages are involved in IL-17 release in sarcoid lungs. The main manifestation of sarcoidosis is an accumulation of mononuclear inflammatory cells, mostly CD4+ T cells and monocytes/macrophages in involved organs, including the lungs.2 As specified in our ‘Materials and methods’ section, we evaluated cells obtained by filtering bronchoalveolar lavage (BAL) fluid through gauze. A standard morphological and immunological analysis of BAL cellular components was performed. The …
