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Correspondence
ABPA in adulthood: a CFTR-related disorder
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  1. P Lebecque1,
  2. X Pepermans2,
  3. E Marchand3,
  4. A Leonard1,
  5. T Leal2
  1. 1Pediatric Pulmonology & Cystic Fibrosis Unit, Cliniques Universitaires St Luc Université de Louvain, Belgium
  2. 2Department of Genetics, Université de Louvain, Cliniques St Luc, Brussels, Belgium
  3. 3Department of Respiratory Diseases, Université de Louvain, Cliniques de Mont-Godinne, Yvoir, Belgium
  1. Correspondence to Patrick Lebecque, Pediatric Pulmonology & Cystic Fibrosis Unit, Cliniques Universitaires St Luc Université de Louvain, 10 avenue Hippocrate, 1200 Brussels, Belgium; patrick_lebecque{at}hotmail.com

https://doi.org/10.1136/thx.2010.145862

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    In Western countries, allergic bronchopulmonary aspergillosis (ABPA) in childhood is very unusual beyond the context of cystic fibrosis (CF). It is presumed to be different in adulthood, although three studies1–3 reported an increased frequency of cystic fibrosis transmembrane conductance regulator (CFTR) mutations in adults with ABPA. Out of the 63 patients investigated in these studies, none was reported as pancreatic insufficient, all had sweat chloride values <60 mmol/l, only two carried the intron 8 splice variant 5T and a single patient was found to be compound heterozygous for two CFTR mutations. However, Miller et al studied only 10 patients and did not sequence all CFTR exons, while the two other reports, including one from our institution, were hampered by the small number of mutations initially looked for …

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