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Genome-wide Transcriptional Profiling Linked to Social Class in Asthm
  1. Edith Chen (echen{at}psych.ubc.ca)
  1. University of British Columbia, Canada
    1. Gregory Miller (gemiller{at}psych.ubc.ca)
    1. University of British Columbia, Canada
      1. Hope Walker (hopewalker{at}psych.ubc.ca)
      1. University of British Columbia, Canada
        1. Jesusa Arevalo (arevaloj{at}ucla.edu)
        1. UCLA, United States
          1. Caroline Sung (orca1006{at}gmail.com)
          1. UCLA, United States
            1. Steve Cole (scole{at}hopelab.org)
            1. UCLA, United States

              Abstract

              Objectives: Low socioeconomic status (SES) is one of the most robust social factors associated with disease morbidity, including more severe asthma in childhood. However, our understanding of the biological processes that explain this link is limited. In this study, we tested whether the social environment could get "under the skin" to alter genomic activity in children with asthma.

              Design and participants: Two group design of children physician diagnosed with asthma who came from either low or high SES families. Outcomes: Genome-wide transcriptional profiles from T lymphocytes of children with asthma.

              Results: Children with asthma from a low SES background showed overexpression of genes regulating inflammatory processes, including those involved in chemokine activity, stress responses, and wound responses compared to high SES children with asthma. Bioinformatic analysis suggested that decreased activity of CREB and NF-Y, and increased NF-kB, transcriptional signaling mediated these effects. These pathways are known to regulate catecholamine and inflammatory signaling in immune cells.

              Conclusions: This study provides the first evidence in a sample of pediatric patients diagnosed with asthma that the larger social environment can affect processes at the genomic level. Specifically, gene transcription control pathways that regulate inflammation and catecholamine signaling were found to vary by SES in children with asthma. Because these pathways are the primary targets of many asthma medications, these findings suggest that the larger social environment may alter molecular mechanisms that have implications for the efficacy of asthma therapeutics.

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