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Effects of atorvastatin added to inhaled corticosteroids on lung function and sputum cell counts in atopic asthma
  1. Eleanor J Hothersall (e_hothersall{at}yahoo.com)
  1. University of Glasgow, United Kingdom
    1. Rekha Chaudhuri (rekhachaudhuri{at}yahoo.com)
    1. University of Glasgow, United Kingdom
      1. Charles McSharry (cms4q{at}clinmed.gla.ac.uk)
      1. University of Glasgow, United Kingdom
        1. Iona Donnelly (icf3h{at}clinmed.gla.ac.uk)
        1. University of Glasgow, United Kingdom
          1. Jane Lafferty (janelafferty1{at}yahoo.co.uk)
          1. University of Glasgow, United Kingdom
            1. Alex D McMahon (a.mcmahon{at}dental.gla.ac.uk)
            1. University of Glasgow, United Kingdom
              1. Christopher J Weir (chris{at}stats.gla.ac.uk)
              1. University of Glasgow, United Kingdom
                1. Janice Meiklejohn (jan69uk{at}hotmail.com)
                1. University of Glasgow, United Kingdom
                  1. Naveed Sattar (nsattar{at}clinmed.gla.ac.uk)
                  1. University of Glasgow, United Kingdom
                    1. Iain McInnes (ibmi1w{at}clinmed.gla.ac.uk)
                    1. University of Glasgow, United Kingdom
                      1. Stuart Wood (sfw1b{at}clinmed.gla.ac.uk)
                      1. University of Glasgow, United Kingdom
                        1. Neil C Thomson (n.c.thomson{at}clinmed.gla.ac.uk)
                        1. University of Glasgow, United Kingdom

                          Abstract

                          Background: Statins have anti-inflammatory properties that may be beneficial in the treatment of asthma. We tested the hypothesis that atorvastatin added to inhaled corticosteroids treatment improves lung function and airway inflammation in atopic adults with asthma.

                          Methods: Fifty four adults with atopic asthma were recruited to a double-blind, randomised controlled crossover trial comparing the effect of oral atorvastatin 40 mg daily with that of a matched placebo on asthma control and airway inflammation. Each treatment was administered for 8 weeks separated by a 6-week washout period. The primary outcome was morning peak expiratory flow (PEF). Secondary outcomes included FEV1, asthma control questionnaire score, airway hyperresponsiveness to methacholine, induced sputum cytology and inflammatory biomarkers.

                          Results: At 8 weeks, the change in mean morning PEF, as compared with baseline, did not differ substantially between the atorvastatin and placebo treatment periods [mean difference -0.5 L/min, 95% Cl -10.6 to 9.6, p=0.921]. Values for other clinical outcomes were similar between the atorvastatin and placebo treatment periods. The absolute sputum macrophage count was reduced after atorvastatin compared to placebo [mean difference -45.0x104 cells, 95% Cl -80.1 to -9.7, p=0.029], as was the sputum fluid leukotriene B4 [mean difference -88.1pg/ml, 95% CI -156.4 to -19.9, p=0.014].

                          Conclusion: The addition of atorvastatin to inhaled corticosteroids results in no short-term improvement in asthma control, but reduces sputum macrophage counts in mild to moderate atopic asthma. We speculate that the change in sputum macrophage count suggests potential areas for investigation of statins in other chronic lung diseases.

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