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Prediction equations for single breath diffusing capacity (dlco) in a middle aged caucasian population
  1. Bruce T Thompson (b.thompson{at}alfred.org.au)
  1. Allergy, Immunology and Respiratory Medicine, The Alfred Hospital, Australia
    1. David P Johns
    1. Menzies Research Institute, University of Tasmania, Australia
      1. Michael Bailey
      1. Department of Epidemiology and Preventive Medicine, Monash University, Australia
        1. Joan Raven
        1. Department of Epidemiology and Preventive Medicine, Monash University, Australia
          1. E Haydn Walters
          1. Menzies Research Institute, University of Tasmania, Australia
            1. Michael J Abramson
            1. Department of Epidemiology and Preventive Medicine, Monash University, Australia

              Abstract

              Rationale: There are many reference equations for the measurement of DLCO. However the testing methodologies vary and there are no well-documented studies that develop reference equations for DLCO and alveolar volume (VA) in middle aged and older populations.

              Objectives: 1. Develop reference equations for DLCO in a middle aged population using the current ATS/ERS guidelines; 2. Compare the equations with those commonly used in laboratories around the world.

              Methods: Healthy subjects (498 male and 474 female) aged 45 to 71 years were recruited as part of a larger epidemiological study. All participants completed a respiratory questionnaire and had spirometry and single breath DLCO (corrected for haemoglobin) measurements following ATS/ERS guidelines.

              Results: The mean age was 58 years for males and 57 years for females. For males, factors that predicted DLCO were: Height, Age and Age * Height interaction and being an ex-smoker. For females, factors that predicted DLCO were: Height, Age, Weight and an Age * Height interaction.

              Conclusion: We have described new prediction equations for DLCO in a middle-aged population that require validation in other populations.

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