Article Text

other Versions

PDF

Incidence and predictive factors of lower respiratory tract infections among the very elderly in the general population. The Leiden 85-plus Study.
  1. annemarie sliedrecht (anneslie{at}hotmail.com)
  1. University Medical center Utrecht, Netherlands
    1. wendy den elzen (w.p.j.den_elzen{at}lumc.nl)
    1. Leiden University Medical Center, Netherlands
      1. theo verheij (t.j.m.verheij{at}umcutrecht.nl)
      1. University Medical center Utrecht, Netherlands
        1. rudi westendorp (r.g.j.westendorp{at}lumc.nl)
        1. leiden university medical center, Netherlands
          1. Jacobijn Gussekloo (jgussekloo{at}lumc.nl)
          1. leiden University Medical Center, Netherlands

            Abstract

            OBJECTIVES: To target preventive strategies in old age, we investigated which very elderly are predisposed to developing lower respiratory tract infections.

            DESIGN: Prospective observational follow-up study.

            SETTING: General population.

            PARTICIPANTS: Unselected cohort of 587 participants aged 85 years in Leiden, the Netherlands.

            MEASUREMENTS: As reported in the literature, predictive factors were selected and assessed at baseline. During a five year follow-up period, information on the development of lower respiratory tract infections was obtained from general practitioners or nursing home physicians. Associations between predictive factors were analysed with Cox regression and population attributable risks were calculated.

            RESULTS: The incidence of lower respiratory tract infections among persons aged 85 through 90 years was 94 (95% CI 80-108) per 1000 person-years. After multivariate analysis, history of COPD, smoking, oral glucocorticosteroid use, severe cognitive impairment, history of stroke and declined functional status remained independently associated with the occurrence of lower respiratory tract infections. Smoking was the greatest contributor with a population attributable risk of 32%.

            CONCLUSION: In the very old, smoking, COPD, stroke and declined functional status were associated with the occurrence of lower respiratory tract infections and provide means to target patients at risk of severe health complications.

            Statistics from Altmetric.com

            Request permissions

            If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

            Linked Articles

            • Airwaves
              Wisia Wedzicha