Background: An increase in levels of C-Reactive Protein (CRP), a marker of systemic inflammation is associated with reduced forced expiratory volume in one second, supporting the hypothesis that the pathophysiology of Chronic Obstructive Pulmonary Disease has a systemic inflammatory component. However, few large studies have assessed the relationship between systemic inflammation as measured by CRP and decline in lung function prospectively in a randomly selected population.
Methods: In 1991 we collected data on forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) and a blood sample on 2442 randomly selected adults from a community based cohort. In 2000, we repeated these measures in 1301 individuals. The level of serum CRP, a marker of systemic inflammation was analysed in these samples from 1991 and 2000.
Results: In cross-sectional analyses of data from 1991 and 2000, serum CRP was inversely related to FEV1 and FVC. After adjustment for smoking and other confounders, the difference in FEV1 was - 9ml (95% confidence intervals CI -13 to -5) and -7ml (95% CI -13 to -2) for each mg/L increment in serum CRP in 1991 and 2000 respectively. There was no significant association between baseline serum CRP and decline in FEV1 and FVC over nine years.
Conclusions: Although serum CRP is inversely associated with lung function in cross-sectional studies, there was no effect of a marker of systemic inflammation on decline in lung function over nine years.
- lung function
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.