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Multilocus analysis of atopy in Korean children using multifactor-dimensionality reduction
  1. Heung-Woo Park
  1. Department of Internal Medicine, Seoul National University College of Medicine, Korea, Republic of
    1. Eun-Soon Shin
    1. DNA Link Inc., Korea, Republic of
      1. Jong-Eun Lee
      1. DNA Link Inc., Korea, Republic of
        1. Hyouk-Soo Kwon
        1. Department of Internal Medicine, Seoul National University College of Medicine, Korea, Republic of
          1. Eunyoung Chun
          1. Department of Internal Medicine, Seoul National University College of Medicine, Korea, Republic of
            1. Sun-Sin Kim
            1. Department of Internal Medicine, Seoul National University College of Medicine, Korea, Republic of
              1. Yoon-Seok Chang
              1. Department of Internal Medicine, Seoul National University College of Medicine, Korea, Republic of
                1. Yoon-Keun Kim
                1. Department of Internal Medicine, Seoul National University College of Medicine, Korea, Republic of
                  1. Kyung-Up Min
                  1. Department of Internal Medicine, Seoul National University College of Medicine, Korea, Republic of
                    1. You-Young Kim
                    1. Department of Internal Medicine, Seoul National University College of Medicine, Korea, Republic of
                      1. Sang-Heon Cho (shcho{at}plaza.snu.ac.kr)
                      1. Department of Internal Medicine, Seoul National University College of Medicine, Korea, Republic of

                        Abstract

                        Background: Atopy is considered to be a complex genetic trait and do not follow a simple Mendelian pattern of heritance. It is now well recognized that gene-gene interactions are important in complex genetic disease.

                        Methods: A total of 2,055 ethnically identical subjects aged from 10 to 18 years living in rural areas on Jeju Island, Korea were randomly recruited. Atopy was defined as a positive skin prick test response to one or more common inhalant allergen. We analyzed gene to gene interactions among 12 polymorphic loci in the 7 candidate genes of atopy using multidimensionality reduction method.

                        Results: A significant interaction was found between V297I in the gene coding vascular endothelial growth factor receptor 2 (KDR) and -308G>A in the gene coding tumor necrosis factor α (TNF) on the risk of atopy, with a cross-validation consistency of 10 of 10 and a prediction error of 35.9% (P = 0.001). Conventional logistic regression also revealed significant interactions between KDR and TNF for atopy. Individuals with the variant allele of -308G>A in TNF (GA or AA) and V297I in KDR (VI or II) had a significant higher risk of atopy [OR (95%CI) = 2.23 (1.48-3.57)].

                        Conclusion: KDR and TNF may synergistically influence on the development of atopy through gene-gene interaction in Korean children and adolescents.

                        • Atopy
                        • Gene-gene interaction
                        • Tumor necrosis factor á
                        • Vascular endothelial growth factor receptor 2

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