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  1. The Triumvirate
  1. Correspondence to The Triumvirate ; alan.smyth{at}nottingham.ac.uk

https://doi.org/10.1136/thoraxjnl-2018-211984

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    The goose that lays the golden egg

    Jak and the beanstalk is a confusing and conflicted tale. Jack is rewarded for disobeying his mother, stealing from a giant, and ultimately killing the giant from whom he stole. JAK2 is also somewhat conflicted as described by Dr Milara and colleagues in this issue of Thorax with high levels of JAK2 being found in the pulmonary arteries of patients with IPF with and without associated pulmoanry hypertension (see page 519). In this story however, inhibiting JAK2 either with JSI-124 or siRNA prevented endothelial and smooth muscle transition, promoted relaxation of pulmonary arteries and ameliorated blemoycin induced lung fibrosis and pulmonary hypertension. So maybe blocking JAK2 will actually be the goose that lays the golden egg in IPF?

    Maybe tomorrow

    As the Stereophonics mused in the early naughties “I look around at a beautiful life; Been the upperside of down; Been the inside of out; But we breathe; We breathe”. However patients with IPF struggle with this last bit, but they may have similar aspirations to “I wanna breeze and an open mind; I wanna swim …

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