Article Text

PDF
Donor intravascular monocyte trafficking: a potential therapeutic target for primary graft dysfunction following lung transplantation?
  1. Christopher Andrew Lamb1,2,
  2. John Andrew Kirby1
  1. 1 Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
  2. 2 Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK
  1. Correspondence to Dr Christopher Andrew Lamb, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE2 4HH, UK; christopher.lamb{at}newcastle.ac.uk

Statistics from Altmetric.com

Ischaemia reperfusion injury at the time of lung transplantation may lead to primary graft dysfunction (PGD).1 Occurring within the first 72 hours following allograft reperfusion, PGD is characterised by hypoxaemia and alveolar infiltrates in the transplanted organ and occurs in up to 30% of patients.2 The development of PGD carries significant early mortality of up to 50% in 30 days.3 Those who survive the early postoperative period have a higher propensity to develop bronchiolitis obliterans syndrome,4 and long-term mortality is also higher at 1, 5 and 10 years.5

Several risk factors have been identified for the development of PGD, including a donor history of smoking, higher FiO2 at the time of reperfusion, elevated pulmonary arterial pressures, large volume blood transfusion and raised recipient body mass index.6 This observation has led to the development of ex vivo lung perfusion. Here. lungs are ventilated and perfused with an acellular buffer. The use of this technique has allowed longer total ischaemic time prior to transplantation without an increase in incidence of PGD.7 However, incomplete understanding of the immune mechanisms leading to ischaemia reperfusion injury is a major limitation to preventing disease onset. There are no disease-specific therapeutics available for the condition, nor to prevent progression to PGD. Improved understanding of the immune responses underlying ischaemia reperfusion injury may allow development of new therapeutic strategies.

Dysregulation of the innate immune response is central to ischaemia reperfusion pathobiology. Neutrophils …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Linked Articles

  • Lung transplantation
    Kate Colette Tatham Kieran Patrick O'Dea Rosalba Romano Hannah Elizabeth Donaldson Kenji Wakabayashi Brijesh Vipin Patel Louit Thakuria Andre Rudiger Simon Padmini Sarathchandra Harefield POPSTAR investigators, Nandor Marczin Masao Takata Harefield POPSTAR investigators Anna Reed Fabio De Robertis Toufan Bahrami Mohamed Amrani Aron-Frederik Popov Prashant N Mohite Anton Sabashnikov Nikhil P Patil Diana Garcia-Saez Bartlomeij Zych Simona Soresi Martin Carby Paras Dalal Mark Griffiths