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Journal Club Summaries
What’s hot that the other lot got
  1. Candy Lee
  1. Correspondence to Dr Candy Lee, Respiratory Medicine and General Internal Medicine, Abertawe Bro Morgannwg University Health Board, Princess of Wales Hospital, Coity Road, Bridgend, CF31 1LD, UK ; clee128{at}doctors.org.uk

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Non-malignant pleural effusion

This UK prospective study (Walker et alChest 2017;151:1099–105) assessed the mortality risk and associated prognostic factors for patients with non-malignant pleural effusions (NMPE). A total of 782 patients were included, of whom 356 (46%) were diagnosed with NMPE. Effusions secondary to organ dysfunction were reported by the authors to have an ‘extremely high’ 1 year mortality. Pleural effusions secondary to cardiac, renal and hepatic failure had a reported 1 year mortality of 50%, 46% and 25%, respectively. The presence of bilateral effusions (HR 3.55; 95% CI 2.22 to 5.68) or a transudative effusion (HR 2.78; 95% CI 1.81 to 4.28) was found to be associated with a worse prognosis, with an increased 1 year mortality rate of 57% and 43%, respectively. NMPE is common and can cause significant morbidity and mortality. The authors conclude that clinicians should be aware of the poor prognostic features in NMPE and guide management accordingly.

Mepolizumab and refractory eosinophilic granulomatosis with polyangiitis

In this phase 3, randomised, placebo controlled, double blind, multicentre study (Wechsler et alN Engl J Med 2017;376:1921–32), mepolizumab, an anti-interleukin 5 monoclonal antibody, was shown to …

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