We studied the effects of high flow oxygen therapy (HFOT) versus non-invasive ventilation (NIV) on inspiratory effort, as assessed by measuring transdiaphragmatic pressure, breathing pattern and gas exchange. Fourteen patients with hypercapnic COPD underwent five 30-min trials: HFOT at two flow rates, both with open and closed mouth, and NIV, applied in random order. After each trial standard oxygen therapy was reinstituted for 10 min. Compared with baseline, HFOT and NIV significantly improved breathing pattern, although to different extents, and reduced inspiratory effort; however, arterial carbon dioxide oxygen tension decreased but not significantly. These results indicate a possible role for HFOT in the long-term management of patients with stable hypercapnic COPD.
Trial registration number NCT02363920.
- Respiratory Measurement
- Long Term Oxygen Therapy (LTOT)
- Non invasive ventilation
- COPD Pathology
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Contributors LP, study design, experimental procedure, writing and data analysis. LF, study design, data analysis. NC, data analysis and experimental procedure. VC, experimental procedure. MAM, statistical analysis. MB, experimental procedure. DB, experimental procedure. EC, data analysis and writing. PN, study design and writing. SN, study design, experimental procedure, data analysis and writing.
Competing interests None declared.
Patient consent Obtained.
Ethics approval Comitato Etico Indipendente dell'Azienda Ospedaliero-Universitaria di Bologna, Policlinico S. Orsola-Malpighi.
Provenance and peer review Not commissioned; externally peer reviewed.
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