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S97 Annual rate of fvc decline in various patient sub-groups with idiopathic pulmonary fibrosis treated with pirfenidone: pooled analysis from 3 pivotal studies
  1. PW Noble1,
  2. C Albera2,
  3. W Chou3,
  4. U Costabel4,
  5. B Day3,
  6. I Glaspole5,
  7. MK Glassberg6,
  8. L Lancaster7,
  9. DJ Lederer8,
  10. SD Nathan9,
  11. CA Pereira10,
  12. J Stauffer3,
  13. JJ Swigris11
  1. 1Cedars-Sinai Medical Centre, Los Angeles, CA, USA
  2. 2University of Turin, Turin, Italy
  3. 3Genentech, Inc., South San Francisco, CA, USA
  4. 4Ruhrlandklinik, University of Duisburg-Essen, Essen, Germany
  5. 5Alfred Hospital and Monash University, Melbourne, Australia
  6. 6University of Miami School of Medicine, Miami, FL, USA
  7. 7Vanderbilt University Medical Centre, Nashville, TN, USA
  8. 8Columbia University Medical Centre, New York, NY, USA
  9. 9Inova Fairfax Hospital, Falls Church, VA, USA
  10. 10Paulista School of Medicine, Federal University of São Paulo, São Paulo, Brazil
  11. 11National Jewish Health, Denver, CO, USA

Abstract

Introduction Pirfenidone has been shown to decrease the annual rate of decline in forced vital capacity (FVC) volume in patients with idiopathic pulmonary fibrosis (IPF). This analysis explored this effect in various patient subgroups.

Methods Patients randomised to pirfenidone 2403 mg/d or placebo in the CAPACITY or ASCEND studies were included. The annualised rate of decline in FVC volume from baseline through 12 months was estimated using a mixed-effects model, with study, time-by-treatment, age-by-sex and height-by-sex as fixed effects and patients and time-by-patient (slope) as random effects. The annual rate of FVC decline was estimated from the slope within the subgroups, defined by demographics and baseline disease activity measures.

Results A total of 623 patients in the pirfenidone group and 624 in the placebo group were included in the pooled analysis. Overall, the adjusted annual rate (SE) of FVC decline from baseline to 12 months was −109.0 (13.6) mL for pirfenidone vs −207.5 (13.7) mL for placebo, a difference of 98.5 (17.5) mL. The annual rate of FVC decline favoured pirfenidone over placebo across various baseline demographic and lung function subgroups (Figure 1).

Conclusions Patients with IPF treated with pirfenidone, regardless of baseline demographic or lung function, had a significantly lower annual rate of decline in FVC volume vs those treated with placebo after 12 months.

Abstract S97 Figure 1

Difference in Annual Rate of FVC Decline (mL) Between Treatment Group and 95% CI

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