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Exercise and COPD
A direct relationship between physical inactivity and mortality following COPD-related hospitalisation was demonstrated by the authors of this retrospective cohort study (ERJ Open Research 2016;2. doi:101183/23120541.00062-2015). Inactive patients had an almost fourfold higher adjusted risk of mortality from COPD-related causes than active patients. Different levels of activity were shown to have an impact on mortality, with patients with COPD who engaged in some activity (defined as 1–149 min/week) and those that engaged in moderate to vigorous exercise (>150 min/week) having a 28% and 47% reduction in the risk of death, respectively, in the 12 months after hospital admission, compared with inactive patients.
Antacids in pulmonary fibrosis
Gastro-oesophageal reflux is highly prevalent in patients with idiopathic pulmonary fibrosis and speculated to have a potential role in pathogenesis and progression. In this study (Lancet Resp Med 2016. pii: S2213-2600(16)00067-9), the authors undertook a pooled post hoc analysis of data from the placebo group of three pirfenidone trials to investigate the effect of antacid treatment on disease progression. No significant difference in disease progression or mortality was seen at …