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P23 Q/A METHOD -A novel way of assessing pulmonary artery stiffness in COPD using cardiac MRI
  1. S Saikia1,
  2. NS Gale1,
  3. JCL Rodrigues2,
  4. RG Wise3,
  5. C Bucciarelli-Ducci2,
  6. JR Cockcroft1,
  7. DJ Shale1
  1. 1Wales Heart Research Institute, School of Medicine, Cardiff University, Cardiff, UK
  2. 2Bristol Heart Institute, University Hospitals Bristol NHS Foundation Trust, Bristol, UK
  3. 3Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, UK

Abstract

Background Pulmonary artery distensibility and pulsatility has been studied in patients with COPD using cardiac MRI (CMRI).1 However, pulmonary artery pulse wave velocity (PA-PWV) using the ‘QA’method2 in CMRI has not been studied in this population. We hypothesised that patients with COPD have a higher PA-PWV compared to healthy individuals.

Methods This interim analysis includes 23 COPD and 12 healthy volunteers (current or ex-smokers free from respiratory disease). All participants underwent spirometry to measure FeV1, FVC and their ratio, oxygen saturations, heart rate, peripheral mean arterial pressure (MAP), 6-minute-walk-distance (6MWD) and cardiac MRI to measure PA-PWV.

MRI studies were performed using a 3.0T GE Signa HDx MRI scanner (GE Healthcare). Phase-contrast cross-sectional images of the pulmonary artery using steady-state free precession sequence were obtained, approximately 2 cm above the pulmonary valve, under free-breathing conditions.

Results Patients with COPD and the healthy individuals were similar in age and gender (Table 1). Patients with COPD had impaired lung function, greater PA-PWV (3.37 ± 0.62 vs 1.4 ± 0.4, p = <0.001*), heart rate and mean arterial pressure than the healthy individuals. Male patients with COPD had greater PA-PWV (3.63 ± 0.45) than females (3.11 ± 0.59) p = 0.042. PA-PWV did not relate to age, lung function, resting oxyyen saturations, heart rate or peripheral MAP.

Abstract P23 Table 1

 

Conclusion Pulmonary artery PWV measured using CMRI ‘QA’ method showed that COPD patients have a stiffer pulmonary artery than healthy individuals. Further analysis will investigate the association between pulmonary artery stiffness and cardiac function.

References 1 Liu C-Y, Jiang R, Dashnaw S, et al. Pulmonary artery stiffness in chronic obstructive pulmonary disease (COPD) - the MESA COPD study. JCMR 2011;13(Suppl 1):P73

2 Peng H-H, Chung HW, Yu HY, Tseng WY. Estimation of pulse wave velocity in main pulmonary artery with phase contrast MRI: preliminary investigation. JMRI 2006;24:1303–1310

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