Article Text

This article has a correction. Please see:

PDF
P152 Fluticasone furoate (FF)/Vilanterol (VI) once daily reduces asthma symptoms both day and night
  1. DA Leather1,
  2. R Forth2,
  3. L Yates1,
  4. LA Jacques3
  1. 1GlaxoSmithKline Respiratory Global Franchise, London, UK
  2. 2PAREXEL International Research Triangle Park, Durham, USA
  3. 3Respiratory Medicines Development Centre, GlaxoSmithKline, London, UK

Abstract

Introduction and objectives FF/VI is the first once daily inhaled corticosteroid/long-acting b2-agonist combination available for the treatment of asthma. Results from five phase III studies that have previously been presented demonstrated a sustained 24 h improvement in lung function and improvement in symptom-free 24 h periods.

Methods Post-hoc analyses of diary card data from these studies were performed to examine whether there was any difference in the contribution of the day and night time symptom-free period to the 24 h symptom-free period. The diary card scale used is described below.

Day-time Symptom Score:

0 = No symptoms during the day

1 = Symptoms for one short period during the day

2 = Symptoms for two or more short periods during the day

3 = Symptoms for most of the day which did not affect my normal daily activities

4 = Symptoms for most of the day which did affect my normal daily activities

5 = Symptoms so severe that I could not go to work or perform normal daily activities

Night-time Symptom Score:

0 = No symptoms during the night

1 = Symptoms causing me to wake once (or wake early)

2 = Symptoms causing me to wake twice or more (including waking early)

3 = Symptoms causing me to be awake for most of the night

4 = Symptoms so severe that I did not sleep at all

To be counted as symptom-free during the day or night the patient needed to record a score of 0.

Results The post-hoc analyses demonstrated that the improvements in day and night time symptom –free periods were similar to the 24 h symptom free periods. See Figure 1 below.

Conclusions In general benefits in symptom free days and symptom free nights contributed to the benefit of FF/VI over comparator groups in terms of 24 h symptom free periods.

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Linked Articles

  • PostScript
    BMJ Publishing Group Ltd and British Thoracic Society