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P118 Factors affecting concordance with continuous positive airway pressure (CPAP) in obstructive sleep apnoea syndrome (OSAS)
  1. N Shilliday1,
  2. A Bishopp1,
  3. B Chakraborty2,
  4. M Daniels1,
  5. R Mukherjee1
  1. 1Birmingham Heartlands Hospital, Birmingham, UK
  2. 2School of Mathematics, University of Birmingham, Birmingham, UK

Abstract

Introduction and objectives The benefits of continuous positive airways pressure in the treatment of obstructive sleep apnoea syndrome have been well established. Despite this, CPAP adherence remains a significant issue resulting in many patients not receiving adequate treatment. A number of variables have been suggested as contributing to non-concordance, however study results have been inconsistent. Studies assessing long term concordance, suggest severity of OSAS and sleepiness to be good predictors of this. This scientific survey looked at the influence of co-morbidity and the severity of OSAS as represented by apnoea hypopnoea index (AHI) at diagnosis on the usage and concordance with CPAP.

Methods Data from 230 patients completing annual follow up after initiation of CPAP by 31st December 2014 was collected retrospectively. The presence and severity of co-morbidity was assessed by the Adult Co-morbidity Evaluation- 27 (ACE-27) score. CPAP usage per day was averaged over the preceding year. The association between usage and initial AHI (data available for 207 patients) was analysed by linear regression. The association between usage and ACE-27 score was analysed by ANOVA.

Results The regression coefficient for initial AHI against CPAP usage shows a statistically significant effect ([p = 0.00126] fitted equation: concordance = 4.161 + 0.024 × AHI). There was no significant difference in CPAP usage between different ACE-27 groups. Further analysis of individual co-morbidities revealed significance in four categories; cardiac arrhythmia (p = 0.031), coronary artery disease (p = 0.006), congestive heart failure (p = 0.045) and malignancy (p = 0.001).

Conclusion AHI at diagnosis remains a strong determinant of CPAP concordance at 1 year. Severity of co-morbidity cannot be conclusively demonstrated to influence usage however further studies into overall and specific co-morbidities are warranted.

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