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Weight loss in obese patients with asthma
Weight reduction in obese patients with asthma has been found to improve asthma severity, airway hyper-responsiveness, asthma control, lung function and quality of life in this Canadian, prospective, controlled, parallel-group study (Chest 2015;147:1582–90. doi: 10.1378/chest.14-3105). Twenty-two patients with a mean body mass index of 45 were involved in this study. Sixteen patients followed a 3-month behavioural weight reduction programme with the remaining six patients acting as controls. After 3 months, a mean weight loss of 16.5 kg was seen in patients involved in the weight reduction programme compared with a mean weight gain of 0.6 kg in the control group. Significant improvement was seen in airway hyper-responsiveness (p=0.009), FEV1 (p=0.009), FVC (p=0.010), asthma control (p=0.001) and asthma quality of life (p=0.003) in the intervention group. There was no significant change in these parameters within the control group. The study supports the active treatment of comorbid obesity in individuals with asthma.
High flow oxygen in acute hypoxaemic respiratory failure
In this open label, multicentre, randomised control trial, treatment with high flow oxygen was shown to improve survival …