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Correspondence
Nitrogen washout measurements of lung clearance index (LCI)
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  1. Andrew Bush1,2,
  2. Samantha Irving1
  1. 1 Department of Paediatrics, Royal Brompton and Harefield NHS Foundation Trust, London, UK
  2. 2 Imperial College London, London, UK
  1. Correspondence to Professor Andrew Bush, Department of Paediatrics, Royal Brompton and Harefield NHS Foundation Trust, SW3 6NP London, UK; a.bush{at}imperial.ac.uk

https://doi.org/10.1136/thoraxjnl-2015-207309

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    The data of Nyilas et al 1 relating nitrogen washout measurements of lung clearance index (LCI) to spirometry in primary ciliary dyskinesia (PCD) are a welcome addition to the current debate.2–5 However, as with the data of Boon et al,4 most of their PCD patients had normal spirometry, so it would be premature to conclude that this relationship holds over the full range of severity of PCD. The suggestion that the relationship may be different in different populations of PCD patients is indeed interesting, and there is considerable genetic variability, as well as management differences across Europe.6 This could be resolved by data sharing across the large European PCD consortia such as BESTCILIA.

    References

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      . Further evidence for an association between LCI and FEV1 in patients with PCD. Thorax 2015; 70:896. doi:10.1136/thoraxjnl-2015-207206
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    Footnotes

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; internally peer reviewed.

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