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A new test for lung cancer screening
With ongoing debate about a screening programme for lung cancer in the UK, this case–control study in Lung Cancer (DOI http://dx.doi.org/10.1016/j.lungcan.2015.03.011) may help by potentially providing a new test to ascertain at-risk individuals who could then have a CT scan.
The study used fluorescent in situ hybridisation to look at telomere length variation (TLV) and mean telomere length in blood lymphocytes. One hundred and ninety-one patients with newly diagnosed non-small cell lung cancer and 207 healthy matched controls were tested. TLV across all chromosomal ends was significantly associated with lung cancer risk; adjusted ORs were 4.67 (95% CI 1.46 to 14.9) for younger patients (<60 years) and 0.46 (95% CI 0.25 to 0.84) for older patients (age >60 years). TLV and mean telomere length jointly affected lung cancer risk: when comparing individuals with short telomere length and high TLV to those with long telomere length and low TLV, adjusted ORs were 8.21 (95% …
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