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Inconsistent results or inconsistent methods? A plea for standardisation of biomarker sampling in mesothelioma studies
  1. Kevin G Blyth1,2
  1. 1Department of Respiratory Medicine, Southern General Hospital, Glasgow, UK
  2. 2Institute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow, UK
  1. Correspondence to Dr Kevin G Blyth, Department of Respiratory Medicine, Long-Term Ventilation Unit, Southern General Hospital, 1345 Govan Road, Glasgow G51 4TF, UK; kevin.blyth{at}

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Reproducibility is a quality that all biomarkers must demonstrate before entering the clinical arena. In October's issue of Thorax, Creaney et al1 reported important diagnostic performance data regarding fibulin-3 in malignant pleural mesothelioma (MPM). Their results (plasma area under the curve (AUC) 0.671, sensitivity 21%) are remarkably discordant with those reported by Pass et al,2 using the same assay in a similarly designed study (plasma AUC 0.974–0.997, sensitivity 97%). Although some discordance is expected, this pattern is common in the MPM biomarker …

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