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Thanks to Turner et al for commenting on our article. Turner et al challenge our finding that the Bacillus Calmette-Guérin vaccine (BCG) can prevent Mycobacterium tuberculosis infection (MTI), and propose an alternative explanation: that the absence of a positive interferon gamma release assay (IGRA) could be due to antigenic sin and does not necessarily demonstrate absence of infection.
A positive IGRA is the best available surrogate for MTI, but we are fully aware of its limitations. With the IGRA test, MTI is defined by a T-cell-induced interferon gamma response to M tuberculosis antigens …