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Correspondence
Author's response: BCG and infection with Mycobacterium tuberculosis
  1. S W Michelsen1,
  2. E M Agger2,
  3. S T Hoff2,
  4. B Soborg1,
  5. L Carstensen1,
  6. A Koch1,
  7. T Lillebaek3,
  8. H C F Sorensen4,
  9. J Wohlfahrt1,
  10. M Melbye1
  1. 1 Department of Epidemiology Research, Statens Serum Institut, Copenhagen S, Denmark
  2. 2 Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen S, Denmark
  3. 3 International Reference Laboratory of Mycobacteriology, Statens Serum Institut, Copenhagen S, Denmark
  4. 4 The Tasiilaq District Hospital, Tasiilaq, Greenland
  1. Correspondence to Dr Sascha Wilk Michelsen, Department of Epidemiology Research, Statens Serum Institut, Artillerivej 5, Copenhagen S DK-2300, Denmark; swm{at}ssi.dk.

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Thanks to Turner et al for commenting on our article. Turner et al challenge our finding that the Bacillus Calmette-Guérin vaccine (BCG) can prevent Mycobacterium tuberculosis infection (MTI), and propose an alternative explanation: that the absence of a positive interferon gamma release assay (IGRA) could be due to antigenic sin and does not necessarily demonstrate absence of infection.

A positive IGRA is the best available surrogate for MTI, but we are fully aware of its limitations. With the IGRA test, MTI is defined by a T-cell-induced interferon gamma response to M tuberculosis antigens …

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