Article Text

BCG and infection with Mycobacterium tuberculosis
  1. Richard D Turner,
  2. Conor D Tweed,
  3. Jilna Shukla,
  4. Graham H Bothamley
  1. Department of Respiratory Medicine, Homerton University Hospital, London, UK
  1. Correspondence to Dr Richard D Turner, Department of Respiratory Medicine, Homerton University Hospital, Homerton Row, London E9 6SR, UK; richard.turner{at}

Statistics from

Michelsen and colleagues1 usefully add to the evidence for the protective effect of BCG against active TB. However, we are puzzled by the conclusion that BCG also prevents Mycobacterium tuberculosis (Mtb) infection. Others have similarly used interferon gamma release assay (IGRA) responses as a surrogate for Mtb infection with similar conclusions.2 ,3

A positive IGRA response represents a previous interaction with Mtb that was sufficient to lead to an acquired immune response. The authors demonstrate a reduced incidence of IGRA response in individuals vaccinated with BCG despite continued risk of Mtb exposure.

The authors’ hypothesis that …

View Full Text

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Linked Articles