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Lobectomy associated with better outcomes in elderly patients with early lung cancer
Survival outcomes of three treatments used for early stage non-small cell lung cancer (NSCLC) was examined in this large, retrospective, population-based study (JAMA Surg 2014; doi: 10.1001/jama surg.2014.556). The authors assessed data on 9093 patients who received definitive treatment with lobectomy, sublobar resection or stereotactic ablative radiotherapy (SABR) between 2003 and 2009. Median age of the patients was 75 years. 79.3% of patients underwent lobectomy, 16.5% had sublobar resections and 4.2% received SABR. After using propensity score matching analysis and proportional hazards regression, lobectomy was found to be associated with better overall survival and lung-specific survival when compared to sublobar resection despite the higher associated surgical risk. SABR was found to have comparable long-term survival outcomes with lobectomy. As such, the authors conclude that SABR may be a good alternative to surgery for patients with very advanced age and multiple co-morbidities.
Long-term erythromycin and respiratory microbiota in bronchiectasis
In this study (Lancet Respir Med 2014; doi: 10.1016/S2213-2600(14)70213–9), gene sequencing of paired sputum samples, taken at baseline and at week 48, …