Article Text

PDF
P10 The Effect Of Naltrexone, An Opioid Receptor Antagonist, On Capsaicin Evoked Cough, In Healthy Male Subjects
  1. I Satia,
  2. K Holt,
  3. E Hilton,
  4. AA Woodcock,
  5. J Smith
  1. Centre for Respiratory and Allergy Research, University of Manchester, Manchester, UK

Abstract

Introduction Chronic cough is a troublesome condition that reduces patient quality of life. Recent evidence suggests that healthy females cough more than healthy males but the mechanism underlying this in unclear.1 We hypothesise that opiate-sensitive inhibitory control mechanisms determine capsaicin-evoked cough responses in healthy subjects.

Aim To show that in healthy males the number of capsaicin-evoked coughs is increased following administration of naltrexone, an opiate receptor antagonist, compared with placebo.

Method 15 male subjects (median age 30 yrs (21–59)) were recruited in to a randomised double blind cross-over trial of single doses of naltrexone vs. placebo given 1 week apart. A capsaicin inhalational challenge (doubling doses 0.48 to 125[micro]M) was performed 60 min after ingestion of naltrexone/placebo using a dosimeter. Four inhalations 30 seconds apart were performed at each concentration and the total coughs evoked at each dose were recorded and verified using a cough monitor.

Results There was a tendency for subjects to cough more when treated with naltrexone (16.7 ± 2.7 (SEM) compared with placebo (13.7 ± 1.6), (p = 0.11, general estimating equations). See Figure 1

Conclusion This small pilot study suggest that opiate sensitive inhibitory mechanisms may have a role in controlling the cough reflex even in healthy subjects.

References

  1. Hilton EC, Baverel PG, Woodcock A, Van Der Graaf PH, Smith JA. J Allergy Clin Immunol. 2013 Oct;132(4):847–55

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.