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Thorax 69:385-386 doi:10.1136/thoraxjnl-2013-204670
  • PostScript
  • Correspondence

Letter in response to Tashkin et al: limited generalisability of uplift findings to clinical practice

  1. Richard Beasley1,2,3,4
  1. 1 Medical Research Institute of New Zealand, Wellington, New Zealand
  2. 2 Capital & Coast District Health Board, Wellington, New Zealand
  3. 3 Victoria University of Wellington, Wellington, New Zealand
  4. 4 University of Otago Wellington, Wellington, New Zealand
  1. Correspondence to Professor Richard Beasley, Medical Research Institute of New Zealand, Private Bag 7902, Wellington 6242, New Zealand; Richard.Beasley{at}mrinz.ac.nz
  • Received 14 October 2013
  • Accepted 16 October 2013
  • Published Online First 8 November 2013

We appreciate the comments made by Tashkin et al 1 regarding the limited generalisability of the Understanding Potential Long-term Impacts on Function with Tiotropium (UPLIFT) findings.2 In response, the sample we studied was not designed to be representative of the general chronic obstructive pulmonary disease (COPD) population, but rather the subgroup of patients with severe COPD who are likely to be at greatest risk of serious cardiovascular events. Second, the derived data presented from the …


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