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This phase three, double-blind, randomised, placebo-controlled, multicentre study was carried out in 30 countries. It compared riociguat (maximum dose 2.5 mg three times a day) with placebo in the treatment of symptomatic pulmonary hypertension.
The primary end point was change in baseline walking distance over 6 min assessed after 12 weeks of treatment. Patients in the riociguat group improved by …
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