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SPLUNC1: link between acidity and dehydration of the airway surface liquid in CF
  1. James P Garnett
  1. Correspondence to Dr James P Garnett, Division of Biomedical Sciences, St George's, University of London, Cranmer Terrace, Tooting, London SW170RE, UK; jgarnett{at}

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Short palate lung and nasal epithelial clone 1 (SPLUNC1) is the most abundant secreted protein in the airways and helps maintain a normal airway surface liquid (ASL) volume through its regulation of the epithelial Na+ channel (ENaC). In cystic fibrosis (CF), it has been proposed that increased Na+ absorption by ENaC contributes to ASL depletion, despite the presence of SPLUNC1.

The study by Garland et …

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