Thorax 68:199-200 doi:10.1136/thoraxjnl-2012-201783
  • Chest clinic
  • Images in Thorax

Unexplained dyspnoea in a patient with idiopathic myelofibrosis

  1. Simon L F Walsh4
  1. 1Department of Radiology, St George's Hospital, London, UK
  2. 2Department of Respiratory Medicine, St George's Hospital, London, UK
  3. 3Department of Histopathology, St George's Hospital, London, UK
  4. 4Department of Radiology, Royal Brompton Hospital, London, UK
  1. Correspondence to Dr Praveen Pissay Gopala Rao, Department of Radiology, St George's Hospital, Blackshaw Road, Tooting, London SW17 0QT, UK; drpgpraveen{at}
  • Received 16 February 2012
  • Accepted 26 May 2012
  • Published Online First 6 July 2012

A 41-year-old with idiopathic myelofibrosis was referred to the chest clinic with a 1-month history of progressive dyspnoea and intermittent wheeze. There was no history of haemoptysis and the patient was a lifelong non-smoker. On examination, the patient was afebrile, cachectic and had hepatosplenomegaly. Haemoglobin was 6.0 g/dl, white cell count 3.6×109/l, platelet count 98×109/l. Blood smear showed marked anisopoikilocytes, prominent tear drop cells and polychromasia. Bone marrow aspirate was hypercellular, showed reduction in the degree of maturation, and a marked decrease in the proportion of erythroid cells. There was no evidence of acute leukaemia or metastatic malignancy. Microbiologic analysis of the sputum and blood for pulmonary infection was negative. Lung function test showed a restrictive …

Relevant Article