Article Text


The development and validation of the King's Sarcoidosis Questionnaire for the assessment of health status
  1. Amit Suresh Patel1,
  2. Richard J Siegert2,
  3. Daniel Creamer3,
  4. Genevieve Larkin4,
  5. Toby M Maher5,
  6. Elisabetta A Renzoni5,
  7. Athol U Wells5,
  8. Irene J Higginson6,
  9. Surinder S Birring1
  1. 1Division of Asthma, Allergy and Lung Biology, King's College London, London, UK
  2. 2School of Public Health and Psychosocial Studies and School of Rehabilitation and Occupational Studies, AUT University, Auckland, New Zealand
  3. 3Department of Dermatology, King's College Hospital, London, UK
  4. 4Department of Ophthalmology, King's College Hospital, London, UK
  5. 5Department of Respiratory Medicine, Royal Brompton Hospital, London, UK
  6. 6Department of Palliative Care, Policy and Rehabilitation, Cicely Saunders Institute, King's College London, London, UK
  1. Correspondence to Dr Surinder S Birring, Division of Asthma, Allergy and Lung Biology, King's College London, Denmark Hill, London SE5 9RS, UK; surinder.birring{at}


Rationale Health status is impaired in patients with sarcoidosis. There is a paucity of tools that assess health status in sarcoidosis. The objective of this study was to develop and validate the King's Sarcoidosis Questionnaire (KSQ), a new modular health status measure.

Methods Patients with sarcoidosis were recruited from outpatient clinics. The development of the questionnaire consisted of three phases: item generation; item reduction, Rasch analysis to create unidimensional scales and validation; repeatability testing.

Results 207 patients with sarcoidosis (organ involvement: 184 lung, 54 skin, 45 eye disease) completed a 65-item preliminary questionnaire. 36 items were removed due to redundancy or poor fit to the Rasch model. The final version of the KSQ consisted of five modules (General health status, Lung, Skin, Eye, Medications). Internal consistency assessed with Cronbach's α coefficient was 0.70–0.93 for KSQ modules. Concurrent validity of the Lung module was high compared with St George's Respiratory Questionnaire (r=−0.83) and moderate when compared to forced vital capacity (r=0.49). Concurrent validity with skin-specific and eye-specific measures ranged from r=−0.4 to 0.8. The KSQ was repeatable over 2 weeks (n=39), intraclass correlation coefficients for modules were 0.90–0.96.

Conclusions The KSQ is a brief, valid, self-completed health status measure for sarcoidosis. It can be used in the clinic to assess sarcoidosis from the patients’ perspective.

  • Sarcoidosis

Statistics from

Key messages

What is the key question?

  • To develop a brief tool to assess the health status of patients with sarcoidosis.

What is the bottom line?

  • The King's Sarcoidosis Questionnaire is a validated tool suitable for clinical and research use.

Why read on?

  • The King's Sarcoidosis questionnaire may become an important outcome parameter in the evaluation of therapies for sarcoidosis.


Sarcoidosis is a multisystem disorder characterised by granulomatous inflammation.1 The lungs are the most frequently affected organ with skin, eye and lymphatics the most common extrapulmonary sites.2 Chronic sarcoidosis often causes significant organ dysfunction and morbidity. Dyspnoea, cough, pain, fatigue, depression, skin disfigurement and visual impairment are frequent symptoms.1 ,3–5 Corticosteroids are often prescribed to treat organ dysfunction and troublesome symptoms. Lung function and other measures such as the Sarcoidosis Severity Tool can be used to assess the severity of pulmonary disease but they do not assess the impact of the disease from the patient's perspective.6 Recent studies have reported a significant impairment in health status of patients with sarcoidosis.4 ,7–9 There is a paucity of sarcoidosis-specific patient-reported outcomes that assess health status. We aimed to develop and validate the King's Sarcoidosis Questionnaire (KSQ), a modular, multi-organ health status measure for patients with sarcoidosis for use in clinic and the evaluation of therapies.


Phase 1: item generation

A preliminary questionnaire was developed following a review of health status and sarcoidosis literature; a review of available health status questionnaires; face-to-face semi-structured and cognitive interviews with 23 consecutive patients with sarcoidosis who were not involved with validation of the preliminary KSQ; and a multi-disciplinary team meeting consisting of respiratory, rheumatology, dermatology, ophthalmology, neurology and palliative care physicians, nurses, a pharmacist, social worker and physiotherapist. The in-depth patient interviews aimed to identify health status issues and explore the impact of their condition. The interviews began with open-ended questions, for example: ‘What is it like to live with your sarcoidosis?’ and ‘How does sarcoidosis affect you?’ Patients were also asked questions about issues anticipated to be relevant to them and to comment on a preliminary KSQ questionnaire. The interviews were repeated until they no longer yielded new themes. A modular questionnaire was developed since sarcoidosis is a condition with variable organ involvement. The questionnaire was worded to assess health status during the previous 2 weeks and patients responded on a seven-point Likert scale. The Likert response scale was derived from a literature review, multi-disciplinary team meeting and patient interviews. The wording of scales was tailored to individual items.


Consecutive patients with sarcoidosis were recruited from secondary care (King's College Hospital) and tertiary care (Royal Brompton Hospital) specialist clinics from May 2010 to January 2011. Clinical characteristics, comorbid medical conditions and medications were recorded using a structured questionnaire. The diagnosis of sarcoidosis and organ involvement was established when there were typical histological and clinical features using the ‘A Case–Control Epidemiologic Study of Sarcoidosis’ definitions.10 Patients self-completed health status questionnaires independently when attending clinic. The questionnaires were administered by a member of the research team not involved in the clinical care of the patient. Patients were excluded from the study if they could not read the questionnaire or completed less than 85% of the questionnaire. The diagnosis of sarcoidosis was established within a multi-disciplinary team of clinicians, radiologists and pathologists. Patients were asked ‘did you find the questionnaire difficult to complete’ and the time taken for completion of the questionnaire was recorded.

Phase 2: item reduction and validation of the KSQ

Item reduction

Items demonstrating a minimum response (floor effect), maximum response (ceiling effect) of ≥60% and the weaker item of those with high inter-item correlations (r>0.8) were removed to minimise redundancy.11

Rasch analysis

The Rasch model provides a template for testing the validity of a questionnaire as a unidimensional measure of the construct it is designed to assess.12 It assumes that the response to an item is determined by two factors; the health status of the person and health status impairment represented by the item. A questionnaire that meets the requirements of a Rasch model has interval scaling properties. Patients are more likely to respond to items assessing less severe health status and less likely to items assessing more severe health status. Rasch analysis is an iterative process whereby the poorest fitting item is removed and the remaining items re-tested until a reliable, unidimensional scale is identified.

Rasch analysis was applied to the KSQ modules and then combinations of modules to create overall scales. The item–trait interaction assessed the questionnaire fit to a unidimensional model. A significant χ2 test for the overall item–trait interaction or individual items indicated misfit to the model and items were therefore removed. Item fit residuals, a summation of the difference between the observed score and that expected by the model for all persons, ≤−2.5 or ≥2.5, indicated the items did not measure the same attribute as the domain and were also removed.13 Summary item and person fit residuals were item–person interaction statistics transformed to approximate a z score; a mean (SD) residual of approximately 0 (1) indicated good fit to the model. The Person Separation Index (PSI) was determined to assess the ability of the KSQ to discriminate patients with different levels of health status impairment and test the reliability of the fit statistics. Internal consistency was assessed using Cronbach's α coefficient. The Likert response scale category thresholds for individual items were collapsed where thresholds were disordered to ensure they represented progressive increments in health status.14 The KSQ module and overall (total) scores were transformed to a range of 0–100 ((actual score−lowest possible score/range)×100); 100=best health status. The influence of age, gender, ethnicity, immunosuppressant medication and organ involvement on the patient's response to items was assessed for differential item functioning (DIF).

Concurrent validity

Concurrent validity, the assessment of an instrument against other standards that provide an indication of disease severity, was assessed by investigating the relationship between KSQ, organ-specific outcome measures and other health status questionnaires. All patients completed the 10-item Fatigue Assessment Scale (FAS) and Short Form-36 (SF36) questionnaire (general health status).15 ,16 For patients with pulmonary sarcoidosis, forced vital capacity was assessed according to American Thoracic Society standards and patients completed the St George's Respiratory Questionnaire (SGRQ; respiratory health status) and the Medical Research Council (MRC) dyspnoea scale.17 ,18 For patients with cutaneous sarcoidosis, an independent dermatologist or trained physician completed a physician's global assessment score of the severity of skin disease (0=no skin involvement, 4=very severe skin involvement) and patients completed the Dermatology life quality index (DLQI), a 10-item dermatology-specific health-related quality of life (HRQOL) tool.19 ,20 For patients with ophthalmic sarcoidosis, visual acuity was assessed with a Snellen chart and a 25-item National Eye Institute Visual function HRQOL questionnaire (NEI-VFQ25) was administered.21 The sequence of administration of questionnaires was KSQ, SF36, SGRQ, MRC dyspnoea scale, FAS, DLQI and NEI-VFQ25. The questionnaires were administered prior to patients being assessed by the clinician or undergoing other procedures.

Phase 3: repeatability testing

A subgroup of consecutive patients with sarcoidosis completed the KSQ questionnaire on two occasions, 2 weeks apart to investigate repeatability. Only patients who reported no change in symptoms and considered stable by the clinician were recruited. Patients were excluded if they had a change in medication within the previous month.


SPSS software, V.18 and RUMM 2030 were used for statistical analysis. Kolmogorov Smirnov test was used to check if the data were normally distributed. Mean and SD were used to describe parametric data. p<0.05 was considered significant except when analysing multiple comparisons (concurrent validity); p≤0.001, stronger evidence of association; p≤0.01 and >0.001, some evidence of association; and p<0.05 and >0.01, possibly due to chance or only suggestive of association. Internal consistency was assessed using Cronbach's α coefficient (acceptable if >0.7).22 Correlations between parameters were assessed with Pearson's (r) coefficient. Univariate analysis was performed to identify an association between health status (General health status and Lung modules) and the independent variables age, gender, ethnicity, smoking, forced expiratory volume in 1 s FEV1%, forced vital capacity (FVC%), transfer factor of the lung for carbon monoxide (TLCO%), Scadding chest x-ray (CXR) stage, number of organs involved and medications. Multivariable ordinary linear regression was used with forward selection to determine independent predictors of General health status and Lung; significant variables identified from univariate analysis (p<0.05) were entered as independent variables. The repeatability of the KSQ was assessed with intraclass correlation coefficients and a Bland Altman plot. The 95% limit of agreement was calculated as 1.96×SD of within-subject differences. All patients gave written informed consent and the study was approved by the local research ethics committee (London–Surrey Borders).


Item generation

Twenty-three patients with sarcoidosis (organ involvement: 22 lung, 10 skin, 7 eye) were interviewed to identify health themes and items. The interviews were discontinued when they did not yield new items. The preliminary KSQ items covered a range of health topics that included breathlessness, other respiratory symptoms, activities, fatigue, pain, social impact, psychological health, medications, health care, relationships and living with skin and eye disease (see online supplementary table 5). The preliminary KSQ was evaluated in 10 patients with sarcoidosis to assess item wording and suitability; no further changes were made. Five preliminary modules were developed during phase 1: General health status (GHS) (29 items), Lung (15 items), Medication (5 items), Skin (8 items) and Eye (8 items). They were administered to 207 patients with sarcoidosis to validate the questionnaire (table 1).

Table 1

Patient demographics

Item reduction and Rasch analysis

Twenty items were removed because of a significant floor effect or high inter-item correlation (figure 1). Rasch analysis removed poorly fitting items in the General health status (12 items), Lung (2), Skin (1) and Medication (1) modules. One Skin health item (‘my skin has been itchy’) was removed because of DIF between Caucasian and Afro-Caribbean patients and borderline redundancy (floor effect 39%). There was no individual item misfit in remaining items and the item–trait interaction was non-significant, indicating good fit to the Rasch model (table 2 and online supplementary table 6). Further details regarding the removal of items are given in online supplementary table 5.

Table 2

Summary of Rasch analysis of KSQ modules

Figure 1

Summary of the development of the King's Sarcoidosis Questionnaire.

The following overall health status scales (combined modules) remained unidimensional following Rasch analysis without eliminating further items: Lung health status (L+GHS), Skin health status (S+GHS), Eye health status (E+GHS) and Lung–Skin health status (L+S+GHS). The addition of the medication module to overall Lung health status and Skin health status scales did not affect the fit to the Rasch model. The addition of the medications module to the overall Eye health status scale did not fit the Rasch model and the medication module was therefore scored separately in patients with eye disease. The PSIs for KSQ modules were 0.8–0.9 (table 2) and for overall health status scales 0.91–0.93, suggesting they had good discriminant power to detect differing levels of health impairment. The person–item maps indicated the KSQ modules and overall scales detected health status across a wide spectrum of health status severity (figure 2 and online supplementary figures 4–11). There was no influence of age, gender, ethnicity, immunosuppressant medication or organ involvement on the response to items (DIF). The response scale thresholds were re-ordered for the following items: 1, 3, 5–11, 16–29. The KSQ scores presented in this study were determined using the re-ordered thresholds.

Figure 2

Person–item threshold distribution for Lung-Health Status score. The x-axis represents severity of health status in logits (log transformed units). The item threshold frequency represents the number of item responses that measure health status at each level of impairment. This figure demonstrates a good spread of item thresholds across the spectrum of health status.

Administration of the KSQ

The final KSQ consists of five modules: General health status (10 items), Lung (6 items), Medication (3 items), Skin (3 items) and Eye (7 items); see appendix. The General health status module is intended to be administered to all patients with sarcoidosis. In addition to this, patients also complete organ-specific modules if relevant to their condition. Overall (total) health status score, the primary outcome measure, is determined by combining modules as described in table 3. The individual module scores are intended to identify the health domains affected. The medication module can be used in isolation or combined with overall lung and skin health status questionnaires but not eye health status. The patients complete the original seven-point Likert scale and scoring is calculated using a re-ordered scale for appropriate items.

Table 3

KSQ: final format

Table 4

The relationship between KSQ and disease-specific outcome measures


The relationship between KSQ modules and their respective disease outcome measures was moderate to strong (table 4). Health status was significantly worse in patients with two or more organ disease compared with single-organ disease: mean (SEM) General health status score 44(3) versus 58(3); mean difference 13; 95% CI of difference 6–21; p=0.001. Patients with Scadding CXR stage 3–4 (severe) pulmonary disease compared with stage 1–2 disease had significantly worse Lung module scores: mean (SEM) 51(4) versus 63(3); mean difference 13; 95% CI of difference 2–23; p=0.019. Female patients had significantly worse General health status scores compared with male patients: mean (SEM) 45(3) versus 57(3); mean difference 12; 95% CI of difference −20 to −4; p=0.002. Univariate analysis identified an association between General health status and FEV1%, FVC%, TLCO%, gender, number of organs involved and immunosuppressant medications. Multivariable analysis (all patients) identified FVC%, gender, number of organs involved and immunosuppressant medications as independent predictors of General health status, accounting for 25% of the variance (see online supplementary table 7). TLCO% was not an independent predictor despite a weak association with General health status (r=0.25, p=0.001). Patients taking immunosuppressive medication had worse FVC% (p=0.015), TLCO% (p<0.001) and greater organ involvement (p=0.048). Univariate analysis (lung patients only) identified an association between the Lung module and FEV1%, FVC%, TLCO%, Scadding CXR stage and immunosuppressant medications. Only FVC% was an independent predictor of the Lung module, accounting for 15% of the variance. There was no multicollinearity. Multivariable analysis was not performed for Skin, Eye and Medication modules due to insufficient sample size. Repeatability was investigated in 39 patients (36 lung, 16 skin, 15 eye involvement). Intraclass correlation coefficients suggested good repeatability; KSQ General health status 0.96, Lung 0.90, Skin 0.92, Eye 0.96 and Medications 0.90. A Bland-Altman plot of KSQ Lung module score repeatability is shown in figure 3. Bland-Altman plots for the other KSQ modules were also consistent, with the KSQ being a highly repeatable measure. Ninety-seven percent of patients had no difficulty in completing the KSQ. The mean (SD) time patients took to complete the KSQ was 10 (8) min.

Figure 3

Bland Altman plot of repeatability of King's Sarcoidosis Questionnaire Lung module. Solid line represents mean difference and dashed lines represent 95% limits of agreement.


The KSQ is a health status questionnaire developed and validated for patients with sarcoidosis. It is brief, adaptable to individual patients and the first tool to assess organ-specific health status. The KSQ is simple to administer and most patients found it easy to complete.

The KSQ items were generated following detailed patient interviews exploring the impact of sarcoidosis on their health. The preliminary KSQ was validated by a systematic statistical approach with Rasch analysis, commonly used in the development of health status tools. Redundant items were removed when possible whilst retaining essential questionnaire measurement characteristics. Rasch analysis confirmed the KSQ modules and overall scales had good interval scaling of items and were unidimensional. The person–item threshold distribution of the KSQ was large, confirming it assessed health status across a wide spectrum. The correlation with lung function in patients with pulmonary sarcoidosis was moderate, analogous to that seen in chronic obstructive pulmonary disease, consistent with the view that health status questionnaires assess a unique aspect of disease severity not captured by objective measures.23 ,24 The concurrent validity of the KSQ compared with the SGRQ was good, suggesting the removal of redundant items did not compromise the KSQ's ability to measure health status. The KSQ correlated more strongly with the SGRQ than the SF36. The weak association with the SF36 raised the possibility that the SF36 did not fully identify the health issues specific for sarcoidosis since it was a generic instrument. The KSQ Skin and Eye modules also related well to organ-specific measures of disease severity. The KSQ detected differences in health status in patients with single-organ compared with multi-organ disease; further studies should investigate whether the KSQ can discriminate health status severity in individual patients.

We chose to develop a flexible, modular instrument that assessed the most frequently involved organs in sarcoidosis to reflect the varied and changing phenotype often seen in clinical practice. The organ-specific modules could be combined with the General health status module to assess overall health status. The General health status module was administered to all patients and could potentially be used to compare the health status of patients with different organ involvement. It may be possible to assess rarer forms of sarcoidosis such as neurological and cardiac disease with the General health status module since it comprises generic items relevant to most patients but this needs to be validated. Further studies are needed to develop disease-specific modules for rarer forms of sarcoidosis. The primary outcome score for the KSQ varies according to organ involvement. For example, in patients with pulmonary sarcoidosis the General health status module is combined with the Lung module to give a total score. There was a very strong correlation between KSQ General health status and fatigue assessed with the FAS (r2=0.74). Fatigue is a very common and troublesome symptom. The data from this study confirm the findings of previous studies reporting a major impact of fatigue on the wellbeing of patients.4 There was no DIF for ethnicity, suggesting that the KSQ was valid for different races. Our findings are consistent with those of Cox et al9 who also found no effect of ethnicity on health status. The relationship between ethnicity, health status and disease severity is likely to be complex and multifactorial and needs further investigation. The KSQ was developed in a large population comprising Caucasian, Afro-Caribbean and other ethnic groups, increasing our confidence that it could be used in a wide range of patients. Female patients had worse health status than male patients, consistent with previous studies.3 ,25

There is one other questionnaire that can be used to assess health status specifically in sarcoidosis, the Sarcoidosis Health Status Questionnaire (SHQ) developed in 2001.9 This is a 29-item questionnaire administered in its entirety. A limitation of the SHQ is that it cannot be tailored to individual clinical phenotypes. This could potentially impact the sensitivity and the responsiveness of the questionnaire. A further limitation is that it contains few items that assess fatigue (one item), medications (one item) and extra-pulmonary organ involvement (skin (one item) and eye disease (one item)). Furthermore, the SHQ has not been validated for use in skin and eye disease. In contrast, organ-specific modules were developed and validated for the KSQ and it can therefore be adapted for individual patients. The KSQ is considerably briefer for most patients, for example, the assessment of lung health status comprises 16 items. This is likely to be important in research studies when patients are often subjected to multiple time-consuming assessments. The KSQ was developed using Rasch analysis in contrast to clinical impact methodology used for the SHQ and therefore has the advantage that it is a validated unidimensional scale with optimal scaling properties.14 The concurrent validity of the KSQ for pulmonary disease was better than that of the SHQ: stronger relationship with SGRQ (r=−0.66 to −0.83 vs −0.62 to −0.73), FVC (r=0.49 vs 0.19) and MRC dyspnoea score (r=−0.62 vs −0.22).9 Furthermore, the KSQ is highly repeatable (test/retest); this has not been reported for the SHQ. The SGRQ, a generic respiratory health status questionnaire could also be used to assess health status in sarcoidosis but has the disadvantage that it is considerably longer (50 items), does not assess skin and eye disease and is likely to be less responsive than disease-specific questionnaires.

There are limitations with health status questionnaire development methodology. It is possible that some items eliminated during the development process such as sleep disturbance and sexual health may have contributed significantly to health status in some patients. Our aim was to develop a questionnaire that could quantify health status with the least number of items, whilst retaining validity, so that it remains practical for clinical use. Health status questionnaires are not a substitute for identifying health-related issues obtained from a detailed history. We eliminated items that were infrequent, redundant, contributed weakly to health status assessment or did not conform to optimal scaling properties. It is possible that health issues relevant to sarcoidosis that were not included in the final version of the KSQ were assessed indirectly by their impact on related health items. For example, sleep disturbance is likely to be associated with difficulty maintaining concentration and fatigue.11 Sleep disturbance is troublesome in a subgroup of patients with sarcoidosis and it is perhaps more appropriate to assess it with sleep-specific tools such as the Epworth Sleepiness Scale.26 Immunosuppressant medication was an independent predictor of General health status. The use of immunosuppressant medications was associated with more severe disease since these patients had worse lung function and a greater number of organs involved, consistent with the findings of a previous study.9 Furthermore, there was no DIF for patients taking immunosuppressive medications. There was no interaction between medications and the Lung module. Another possibility is that side effects of medications, particularly corticosteroids, may have impacted health status more than the effect of sarcoidosis in some patients. Longitudinal studies are needed in patients matched for disease severity to investigate the temporal relationship between medications and health status. The impact of medications should be assessed specifically with the KSQ medication module. The person–item threshold distribution suggested that the KSQ items were marginally more focused towards patients with milder health status. The high PSI for the KSQ was consistent with its ability to discriminate differing levels of health status. However, the responsiveness was not investigated and needs to be assessed in large longitudinal studies and in patients with acute exacerbation of sarcoidosis.

The KSQ has a number of potential applications. The KSQ is a quick and valid tool to identify health status issues important to patients in the clinic. Furthermore, it could be used to help formulate shared care plans between the patient and physician. Our study suggests the KSQ is a valid single point measure that could be used in cross-sectional studies. In summary, the KSQ is brief, easy to administer and well validated. It represents an advance in the assessment of sarcoidosis.


We would like to thank the staff in the clinics and lung function units at King's College Hospital and Royal Brompton Hospital for their assistance in characterisation of patients. We would like to thank Dr Barry Gray and Dr Greg Keir for their assistance in recruiting patients. We would also like to thank Dr Sabrina Bajwah, Dr Rachel Morris-Jones, Professor Roderick Hay and Dr Saquib Bashir for their input into methodology, Professor Andrew Finlay for permission for use of the DLQI and Professors Mike Morgan and Sally Singh for reviewing the KSQ questionnaire.

Reprints of KSQ: the King's Sarcoidosis Questionnaire ©2011 is protected by copyright; King's College Hospital NHS Foundation Trust. Reprints of the KSQ are available from the corresponding author.


King's Sarcoidosis Questionnaire ©

This questionnaire is designed to assess the impact of sarcoidosis on various aspects of your life. Read each question carefully and answer by CIRCLING the response that best applies to you. Please answer ALL questions, as honestly as you can. This questionnaire is confidential. All questions relate to how SARCOIDOSIS has affected your health.

Please note the KSQ is scored using a re-ordered response scale; this is available from the corresponding author. The patients however complete the scale below.

General Health status






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  • Contributors Conception and obtained funding: SB and IH; study design: all; recruitment: AP, DC, GL, TM, ER, AW and SB; analysis and interpretation: AP, RS, AW, IH and SB; data collection: AP; wrote the manuscript: AP and SB; revised the manuscript: IH, RS, AW, DC, GL, TM and ER.

  • Funding King's College Hospital Charity. AW, TM and ER are supported by the NIHR Respiratory Disease Biomedical Research Unit at the Royal Brompton and Harefield NHS Foundation Trust and Imperial College London.

  • Competing interests None.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement All data published in full.

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