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Treating asthma
P3 Oxidative Distress and Antioxidants in Severe Asthma
  1. R Sathyamurthy1,
  2. S Manney2,
  3. C Webster2,
  4. T Krishna2,
  5. G Perkins2,
  6. AH Mansur2
  1. 1James Cook University Hospital, Middlesbrough, United Kingdom
  2. 2Birmingham Heartlands Hospital, Birmingham, United Kingdom

Abstract

Background The role played by oxidative stress (OS) burden and antioxidant (AO) defences in severe asthma (SA) have been inconsistent.

Aims To compare levels of OS markers and AO between subtypes of SA, mild asthma (MA) and control (N).

Methods A longitudinal case control study (2009–2010) included 15 N, 15 corticosteroid naïve MA, 10 SA not dependent on oral corticosteroids (OCS), 10 SA dependent on OCS (NOCS) and 10 type-1 brittle asthma (BA). Subjects taking vitamin supplementation were excluded. Serum AO – vitamin A (vit-A) and E (vit-E), copper(Cu), selenium(s) and zinc (Zn) were measured at first visit. Exhaled breath condensate (EBC) nitrate and 8-isoprostane(iSo), Fractional exhaled Nitric Oxide (FeNO) were measured on 3 visits 3 weeks apart as markers of OS. OS and AO markers were correlated with asthma-severity.

Results Sixty subjects were recruited (16 males, age 19–57 yrs). 8-iSo was not detectable in all of our samples. Significant correlations (p<0.05) between AO and OS markers are given in the table below

Abstract P3 Table 1

Between group analyses revealed correlation of FeNO with increasing asthma-severity, but EBC nitrate did not differ significantly amongst the 5 groups. Vit-A was significantly higher in OCS group, and vit-E was significantly higher in the OCS, NOCS and BA groups as compared to N. There was no significant difference between the 5 groups in Cu, Zn or Se levels. Regression analysis identified age, height, and vit-E as best predictors of FEV1.

Conclusion This study indicates paradoxically increased levels of some of the AO in severe asthmatics. We hypothesise that the mechanics by which AO counteracts the OS in severe asthmatics could be impaired rather than AO deficiency. This needs to be researched further in larger studies.

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