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CFTR potentiator for cystic fibrosis
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  1. Siu P Cho
  1. Correspondence to Dr Siu P Cho, ST3, East Kent Hospitals University NHS Foundation Trust, Kent and Canterbury Hospital, Department of Chest Medicine, Ethelbert Road, Canterbury CT1 3NG, UK; pete.sp.cho{at}gmail.com

https://doi.org/10.1136/thoraxjnl-2011-201512

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    This multicentre, double blinded, randomised controlled trial assessed the efficacy of ivacaftor, a cystic fibrosis transmembrane conductance regulator (CFTR) protein potentiator.

    The primary outcome of the trial was the change in the forced expiratory volume in 1 s (FEV1). The secondary outcomes were time to the first pulmonary exacerbation and subject-reported respiratory symptoms. The trial …

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